WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 463667
CAS#: 127308-98-9 (fumarate)
Description: Zamifenacin fumarate is an antagonist of M3 muscarinic acetylcholine receptors. It is selective for M3 over M1, M2, M4, and M5 receptors in radioligand binding assays using cells expressing recombinant human receptors. Zamifenacin fumarate inhibits cholecystokinin-induced small bowel motility but does not increase heart rate in dogs.
MedKoo Cat#: 463667
Name: Zamifenacin fumarate
CAS#: 127308-98-9 (fumarate)
Chemical Formula: C31H33NO7
Exact Mass: 531.2257
Molecular Weight: 531.605
Elemental Analysis: C, 70.04; H, 6.26; N, 2.63; O, 21.07
Related CAS #: 127308-98-9 (fumarate) 127308-82-1 (free)
Synonym: Zamifenacin fumarate; UK 76654; UK76654; UK-76654;
IUPAC/Chemical Name: (R)-3-(benzhydryloxy)-1-(2-(benzo[d][1,3]dioxol-5-yl)ethyl)piperidine fumarate
InChi Key: PMHKTAIGYOVZEZ-ZHWJIHCSSA-N
InChi Code: InChI=1S/C27H29NO3.C4H4O4/c1-3-8-22(9-4-1)27(23-10-5-2-6-11-23)31-24-12-7-16-28(19-24)17-15-21-13-14-25-26(18-21)30-20-29-25;5-3(6)1-2-4(7)8/h1-6,8-11,13-14,18,24,27H,7,12,15-17,19-20H2;1-2H,(H,5,6)(H,7,8)/b;2-1+/t24-;/m1./s1
SMILES Code: OC(/C=C/C(O)=O)=O.C(C1=CC=CC=C1)(O[C@H]2CN(CCC3=CC=C4OCOC4=C3)CCC2)C5=CC=CC=C5
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 531.605 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
