WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 463652

CAS#: 1478364-87-2

Description: PXS-4681A is a novel potent and selective mechanism-based inhibitor of SSAO/VAP-1 with anti-inflammatory effects in vivo.

Chemical Structure

CAS# 1478364-87-2

Theoretical Analysis

MedKoo Cat#: 463652
Name: PXS-4681A
CAS#: 1478364-87-2
Chemical Formula: C10H14ClFN2O3S
Exact Mass: 296.0398
Molecular Weight: 296.7414
Elemental Analysis: C, 40.48; H, 4.76; Cl, 11.95; F, 6.40; N, 9.44; O, 16.17; S, 10.80

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: PXS-4681A; PXS4681A; PXS 4681A;

IUPAC/Chemical Name: (Z)-4-((2-(aminomethyl)-3-fluoroallyl)oxy)benzenesulfonamide hydrochloride


InChi Code: InChI=1S/C10H13FN2O3S.ClH/c11-5-8(6-12)7-16-9-1-3-10(4-2-9)17(13,14)15;/h1-5H,6-7,12H2,(H2,13,14,15);1H/b8-5-;

SMILES Code: O=S(C1=CC=C(OC/C(CN)=C\F)C=C1)(N)=O.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 296.7414 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Thézénas ML, De Leo B, Laux-Biehlmann A, Bafligil C, Elger B, Tapmeier T, Morten K, Rahmioglu N, Dakin SG, Charles P, Martinez FE, Steers G, Fischer OM, Mueller J, Hess-Stumpp H, Steinmeyer A, Manek S, Zondervan KT, Kennedy S, Becker CM, Shang C, Zollner TM, Kessler BM, Oppermann U. Amine oxidase 3 is a novel pro-inflammatory marker of oxidative stress in peritoneal endometriosis lesions. Sci Rep. 2020 Jan 30;10(1):1495. doi: 10.1038/s41598-020-58362-3. Erratum in: Sci Rep. 2020 Mar 24;10(1):5665. PMID: 32001775; PMCID: PMC6992811.

2: Becchi S, Buson A, Foot J, Jarolimek W, Balleine BW. Inhibition of semicarbazide-sensitive amine oxidase/vascular adhesion protein-1 reduces lipopolysaccharide-induced neuroinflammation. Br J Pharmacol. 2017 Jul;174(14):2302-2317. doi: 10.1111/bph.13832. Epub 2017 Jun 10. PMID: 28437839; PMCID: PMC5481640.

3: Foot JS, Yow TT, Schilter H, Buson A, Deodhar M, Findlay AD, Guo L, McDonald IA, Turner CI, Zhou W, Jarolimek W. PXS-4681A, a potent and selective mechanism- based inhibitor of SSAO/VAP-1 with anti-inflammatory effects in vivo. J Pharmacol Exp Ther. 2013 Nov;347(2):365-74. doi: 10.1124/jpet.113.207613. Epub 2013 Aug 13. PMID: 23943052.