DFN75624
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555897

CAS#: 2253675-62-4 (S-isomer)

Description: DFN75624 is a dengue viral replication inhibitor. DFN75624 was first reported in patent WO 2018215315 (Janssen Pharmaceuticals). DFN75624 has CAS# 2253675-62-4, no formal name. For the convenience of scientific communication, we named it as DFN75624 (combined from Inchi key plus CAS#) according to Hodoodo Chemical Nomenclature (https://hodoodo.com/hodoodo-chemical-nomenclature).


Chemical Structure

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DFN75624
CAS# 2253675-62-4 (S-isomer)

Theoretical Analysis

MedKoo Cat#: 555897
Name: DFN75624
CAS#: 2253675-62-4 (S-isomer)
Chemical Formula: C29H26ClF3N2O6
Exact Mass: 590.1431
Molecular Weight: 590.9802
Elemental Analysis: C, 58.94; H, 4.43; Cl, 6.00; F, 9.64; N, 4.74; O, 16.24

Size Price Shipping out time Quantity
100mg USD 6950 2 Weeks
200mg USD 9650 2 Weeks
500mg USD 14950 2 Weeks
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Pricing updated 2021-02-28. Prices are subject to change without notice.

DFN75624 is in stock

Related CAS #: 2253675-60-2 (racemic)   2253675-61-3 (R-isomer)   2253675-62-4 (S-isomer)    

Synonym: DFN75624; DFN-75624; DFN 75624;

IUPAC/Chemical Name: (1R,2R)-2-((3-(((S)-1-(4-chlorophenyl)-2-oxo-2-(6-(trifluoromethoxy)indolin-1-yl)ethyl)amino)-5-methoxyphenoxy)methyl)cyclopropane-1-carboxylic acid

InChi Key: DPLSNZRPHADTGY-FODJJAHYSA-N

InChi Code: InChI=1S/C29H26ClF3N2O6/c1-39-22-11-20(12-23(13-22)40-15-18-10-24(18)28(37)38)34-26(17-2-5-19(30)6-3-17)27(36)35-9-8-16-4-7-21(14-25(16)35)41-29(31,32)33/h2-7,11-14,18,24,26,34H,8-10,15H2,1H3,(H,37,38)/t18-,24+,26-/m0/s1

SMILES Code: O=C([C@@H](NC1=CC(OC[C@@H]2C[C@H]2C(O)=O)=CC(OC)=C1)C3=CC=C(Cl)C=C3)N4CCC5=CC=C(OC(F)(F)F)C=C54

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Handling Instructions:

Preparing Stock Solutions

The following data is based on the product molecular weight 590.9802 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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Preparation of substituted indoline derivatives as dengue viral replication inhibitors
By: Bonfanti, Jean-Francois; Kesteleyn, Bart Rudolf Romanie; Bardiot, Dorothee Alice Marie-Eve; Marchand, Arnaud Didier M.; Coesemans, Erwin; Fortin, Jerome Michel Claude; Mercey, Guillaume Jean Maurice; Raboisson, Pierre Jean-Marie Bernard.
Assignee: Janssen Pharmaceuticals, Inc., USA; Katholieke Universiteit Leuven.
From: PCT Int. Appl., 2018215315, 29 Nov 2018