ACe-1
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MedKoo CAT#: 412729

CAS#: 2260670-55-9

Description: ACe-1 is a modified ceramide with an azobenzene moiety to allow for optical control of the N-acyl chain. ACe-1 has been shown to enable the reversible switching of lipid domains in raft-mimicking supported bilayers. Research has shown that in the trans- configuration the ACes are in the liquid-ordered phase and in the cis- configuration the ACes are in the liquid disordered phase in lipid rafts.


Chemical Structure

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ACe-1
CAS# 2260670-55-9

Theoretical Analysis

MedKoo Cat#: 412729
Name: ACe-1
CAS#: 2260670-55-9
Chemical Formula: C38H59N3O3
Exact Mass: 605.4556
Molecular Weight: 605.91
Elemental Analysis: C, 75.33; H, 9.82; N, 6.94; O, 7.92

Price and Availability

Size Price Availability Quantity
5.0mg USD 605.0 2 Weeks
25.0mg USD 1899.0 2 Weeks
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Synonym: ACe-1; N-[(E)-4-(4-((4-butylphenyl)diazenyl)phenyl)butanoyl]-D-erythro-sphingosine

IUPAC/Chemical Name: 4-(4-((E)-(4-butylphenyl)diazenyl)phenyl)-N-((2S,3R,E)-1,3-dihydroxyoctadec-4-en-2-yl)butanamide

InChi Key: YLXGVJCCZLVXAT-OYLVPQITSA-N

InChi Code: InChI=1S/C38H59N3O3/c1-3-5-7-8-9-10-11-12-13-14-15-16-17-21-37(43)36(31-42)39-38(44)22-18-20-33-25-29-35(30-26-33)41-40-34-27-23-32(24-28-34)19-6-4-2/h17,21,23-30,36-37,42-43H,3-16,18-20,22,31H2,1-2H3,(H,39,44)/b21-17+,41-40+/t36-,37+/m0/s1

SMILES Code: OC[C@H](NC(CCCC1=CC=C(/N=N/C2=CC=C(CCCC)C=C2)C=C1)=O)[C@H](O)/C=C/CCCCCCCCCCCCC

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 605.91 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Ding H, Kothandaraman S, Gong L, Williams MM, Dirksen WP, Rosol TJ, Tweedle MF. A human GRPr-transfected Ace-1 canine prostate cancer model in mice. Prostate. 2016 Jun;76(9):783-95. doi: 10.1002/pros.23172. Epub 2016 Mar 4. PMID: 26940014; PMCID: PMC5867903.

2: Elanga-Ndille E, Nouage L, Ndo C, Binyang A, Assatse T, Nguiffo-Nguete D, Djonabaye D, Irwing H, Tene-Fossog B, Wondji CS. The G119S Acetylcholinesterase (Ace-1) Target Site Mutation Confers Carbamate Resistance in the Major Malaria Vector Anopheles gambiae from Cameroon: A Challenge for the Coming IRS Implementation. Genes (Basel). 2019 Oct 11;10(10):790. doi: 10.3390/genes10100790. PMID: 31614683; PMCID: PMC6826778.

3: Bkhache M, Tmimi FZ, Charafeddine O, Filali OB, Lemrani M, Labbé P, Sarih M. G119S ace-1 mutation conferring insecticide resistance detected in the Culex pipiens complex in Morocco. Pest Manag Sci. 2019 Jan;75(1):286-291. doi: 10.1002/ps.5114. Epub 2018 Aug 21. PMID: 29885052.

4: Sarkar T, Singh NP, Kar P, Husain SA, Kapoor S, Pollipalli SK, Kumar A, Garg N. Does angiotensin-converting enzyme-1 (ACE-1) gene polymorphism lead to chronic kidney disease among hypertensive patients? Ren Fail. 2016 Jun;38(5):765-9. doi: 10.3109/0886022X.2016.1160247. Epub 2016 Apr 6. PMID: 27050505.

5: Major KM, Weston DP, Lydy MJ, Huff Hartz KE, Wellborn GA, Manny AR, Poynton HC. The G119S ace-1 mutation confers adaptive organophosphate resistance in a nontarget amphipod. Evol Appl. 2019 Nov 27;13(4):620-635. doi: 10.1111/eva.12888. PMID: 32211056; PMCID: PMC7086107.

6: Cui R, Zhang L, Chen Y, Huang W, Fan C, Wu Q, Peng D, da Silva W, Sun X. Expression and evolutionary analyses of three acetylcholinesterase genes (Mi- ace-1, Mi-ace-2, Mi-ace-3) in the root-knot nematode Meloidogyne incognita. Exp Parasitol. 2017 May;176:75-81. doi: 10.1016/j.exppara.2017.01.008. Epub 2017 Feb 24. PMID: 28238686.

7: Al-Qattan KK, Thomson M, Jayasree D, Ali M. Garlic Attenuates Plasma and Kidney ACE-1 and AngII Modulations in Early Streptozotocin-Induced Diabetic Rats: Renal Clearance and Blood Pressure Implications. Evid Based Complement Alternat Med. 2016;2016:8142394. doi: 10.1155/2016/8142394. Epub 2016 May 18. PMID: 27293465; PMCID: PMC4887627.

8: Dušanović Pjević M, Beslac Bumbaširevic L, Vojvodic L, Grk M, Maksimović N, Damnjanović T, Novaković I, Kačar K, Pesic M, Perovic D, Savic M, Maksic V, Trickovic J, Jekic B. Analysis of the Association Between Polymorphisms within PAI-1 and ACE genes and Ischemic Stroke Outcome After rt-PA Therapy. J Pharm Pharm Sci. 2019;22(1):142-149. doi: 10.18433/jpps30339. PMID: 31013014.

9: Assogba BS, Djogbénou LS, Milesi P, Berthomieu A, Perez J, Ayala D, Chandre F, Makoutodé M, Labbé P, Weill M. An ace-1 gene duplication resorbs the fitness cost associated with resistance in Anopheles gambiae, the main malaria mosquito. Sci Rep. 2015 Oct 5;5:14529. doi: 10.1038/srep14529. PMID: 26434951; PMCID: PMC4592963.

10: Assogba BS, Milesi P, Djogbénou LS, Berthomieu A, Makoundou P, Baba-Moussa LS, Fiston-Lavier AS, Belkhir K, Labbé P, Weill M. The ace-1 Locus Is Amplified in All Resistant Anopheles gambiae Mosquitoes: Fitness Consequences of Homogeneous and Heterogeneous Duplications. PLoS Biol. 2016 Dec 5;14(12):e2000618. doi: 10.1371/journal.pbio.2000618. PMID: 27918584; PMCID: PMC5137868.

ACe-1

5.0mg / USD 605.0