YON41660
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 412693

CAS#: 29541-66-0

Description: YON41660 is applicable in the lipid vesicle preparation for protein kinase C activity studies.


Chemical Structure

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YON41660
CAS# 29541-66-0

Theoretical Analysis

MedKoo Cat#: 412693
Name: YON41660
CAS#: 29541-66-0
Chemical Formula: C37H70O5
Exact Mass: 594.5223
Molecular Weight: 594.96
Elemental Analysis: C, 74.70; H, 11.86; O, 13.45

Price and Availability

Size Price Availability Quantity
10.0mg USD 270.0 2 Weeks
25.0mg USD 448.0 2 Weeks
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Synonym: 16:0-18:1 DG; 1-palmitoyl-2-oleoyl-sn-glycerol; 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol DG(16:0/18:1(9Z)/0:0); YON 41660; YON-41660; YON41660

IUPAC/Chemical Name: (S)-1-hydroxy-3-(palmitoyloxy)propan-2-yl oleate

InChi Key: YEJYLHKQOBOSCP-OZKTZCCCSA-N

InChi Code: InChI=1S/C37H70O5/c1-3-5-7-9-11-13-15-17-18-20-22-24-26-28-30-32-37(40)42-35(33-38)34-41-36(39)31-29-27-25-23-21-19-16-14-12-10-8-6-4-2/h17-18,35,38H,3-16,19-34H2,1-2H3/b18-17-/t35-/m0/s1

SMILES Code: OC[C@]([H])(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCCCCCCCCCC)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 594.96 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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Reconstitution Calculator

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1. Eum JY, Lee JC, Yi SS, Kim IY, Seong JK, Moon MH. Aging-related lipidomic changes in mouse serum, kidney, and heart by nanoflow ultrahigh-performance liquid chromatography-tandem mass spectrometry. J Chromatogr A. 2020 Jan 3:460849. doi: 10.1016/j.chroma.2020.460849. Epub ahead of print. PMID: 31928769.

PubMed ID: 31928769

2. Murakami C, Hoshino F, Sakai H, Hayashi Y, Yamashita A, Sakane F. Diacylglycerol kinase δ and sphingomyelin synthase-related protein functionally interact via their sterile α motif domains. J Biol Chem. 2020 Jan 24:jbc.RA119.012369. doi: 10.1074/jbc.RA119.012369. Epub ahead of print. PMID: 31980461.

PubMed ID: 31980461

3. Campbell JM, Tate G, Scott JS. The use of warfarin in pregnancy complicated by circulating lupus anticoagulant; a technique for monitoring. Eur J Obstet Gynecol Reprod Biol. 1988 Sep;29(1):27-32.

PubMed ID: 31478204

4. Thomas LL, van der Vegt SA, Fromme JC. A Steric Gating Mechanism Dictates the Substrate Specificity of a Rab-GEF. Dev Cell. 2019 Jan 7;48(1):100-114.e9. doi: 10.1016/j.devcel.2018.11.013. Epub 2018 Dec 6.

PubMed ID: 30528786

5. Zhang X, Barraza KM, Upton KT, Beauchamp JL. Subtle Changes in Lipid Environment Have Profound Effects on Membrane Oxidation Chemistry. J Am Chem Soc. 2018 Nov 21. doi: 10.1021/jacs.8b08610. [Epub ahead of print]

PubMed ID: 30461271

6. Ebeling, J.G., Vandenbark, G.R., Kuhn, L., Ganong, B., Bell, R.M. & Niedel, J.E. (1985) Diacylglycerols and Phorbol Diesters Induce Leukemic Cell Differentiation via a Common Mechanism. Proc. Natl. Acad. Sci. USA 82:815-819.

7. Davis, R.J., Ganong, B.R., Bell, R.M. & Czech, M.P. (1985) sn-1,2-dioctanoylglycerol: a Cell Permeable Diacylglycerol That Mimics Phorbol Diester Action on the Epidermal Growth Factor Receptor and Mitogenesis. J. Biol. Chem. 260:1562-1566.

8. Lapetina, E.G., Reep, B., Ganong, B.R. & Bell, R.M. (1985) Exogenous sn-1,2-diacylglycerols Containing Saturated Fatty Acids Functions as Bioregulators of Protein Kinase C in Human Platelets. J. Biol. Chem. 260:1358-1361.

9. Ganong, B.R., Loomis, C.R., Hannun, Y.A. & Bell, R.M. (1986) Specificity and Mechanism of Protein Kinase C Activation by sn-1,2-diacylglycerols. Proc. Natl. Acad. Sci. USA 83:1184-1188.

PubMed ID: 3456578

10. Bockelmann S, Mina JGM, Korneev S, Hassan DG, Mueller D, Hilderink A, Vlieg HC, Raijmakers R, Heck AJR, Haberkant P, Holthuis JCM. A search for ceramide binding proteins using bifunctional lipid analogs yields CERT-related protein StarD7. J Lipid Res. 2018 Jan 17. pii: jlr.M082354. doi: 10.1194/jlr.M082354. [Epub ahead of print]

PubMed ID: 29343537

YON41660

10.0mg / USD 270.0