Faropenem sodium hemipentahydrate

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MedKoo CAT#: 575324

CAS#: 158365-51-6

Description: Faropenem sodium hemipentahydrate is an orally active beta-lactam antibiotic belonging to the penem group. It is resistant to some forms of extended-spectrum beta-lactamase.

Chemical Structure

Faropenem sodium hemipentahydrate
CAS# 158365-51-6

Theoretical Analysis

MedKoo Cat#: 575324
Name: Faropenem sodium hemipentahydrate
CAS#: 158365-51-6
Chemical Formula: C24H38N2Na2O15S2
Exact Mass: 704.1509
Molecular Weight: 704.67
Elemental Analysis: C, 40.91; H, 5.44; N, 3.98; Na, 6.53; O, 34.06; S, 9.10

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
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Synonym: (+)-Faropenem sodium hemipentahydrate; Faropenem sodium hemipentahydrate; Faropenem sodium hydrate

IUPAC/Chemical Name: sodium (5R,6S)-6-((R)-1-hydroxyethyl)-7-oxo-3-((R)-tetrahydrofuran-2-yl)-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate pentahydrate


InChi Code: InChI=1S/2C12H15NO5S.2Na.5H2O/c2*1-5(14)7-10(15)13-8(12(16)17)9(19-11(7)13)6-3-2-4-18-6;;;;;;;/h2*5-7,11,14H,2-4H2,1H3,(H,16,17);;;5*1H2/q;;2*+1;;;;;/p-2/t2*5-,6-,7+,11-;;;;;;;/m11......./s1

SMILES Code: O.O.O.O.O.[Na+].[Na+].C[C@@H](O)[C@@H]1[C@H]2SC(=C(N2C1=O)C(=O)[O-])[C@H]3CCCO3.C[C@@H](O)[C@@H]4[C@H]5SC(=C(N5C4=O)C(=O)[O-])[C@H]6CCCO6

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 704.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Woodcock JM, Andrews JM, Brenwald NP, Ashby JP, Wise R. The in-vitro activity of faropenem, a novel oral penem. J Antimicrob Chemother. 1997 Jan;39(1):35-43. PubMed PMID: 9044026.

2: Mortensen JE, Egleton JH. Comparative in vitro activity of furopenem against aerobic bacteria isolated from pediatric patients. Diagn Microbiol Infect Dis. 1995 Jul;22(3):301-6. PubMed PMID: 8565421.

3: Sewell D, Barry A, Allen S, Fuchs P, McLaughlin J, Pfaller M. Comparative antimicrobial activities of the penem WY-49605 (SUN5555) against recent clinical isolates from five U.S. medical centers. Antimicrob Agents Chemother. 1995 Jul;39(7):1591-5. PubMed PMID: 7492110; PubMed Central PMCID: PMC162787.

4: Fuchs PC, Barry AL, Sewell DL. Antibacterial activity of WY-49605 compared with those of six other oral agents and selection of disk content for disk diffusion susceptibility testing. Antimicrob Agents Chemother. 1995 Jul;39(7):1472-9. PubMed PMID: 7492088; PubMed Central PMCID: PMC162765.

5: Cormican MG, Jones RN. Evaluation of the in-vitro activity of furopenem (SY5555 or SUN5555) against respiratory tract pathogens and beta-lactamase producing bacteria. J Antimicrob Chemother. 1995 Apr;35(4):535-9. PubMed PMID: 7628987.