WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 575296
CAS#: 189353-31-9
Description: Fadolmidine is a novel and potent alpha2 -adrenoceptor (alpha2) -AR) agonist developed for spinal analgesia.
MedKoo Cat#: 575296
Name: Fadolmidine
CAS#: 189353-31-9
Chemical Formula: C13H14N2O
Exact Mass: 214.1106
Molecular Weight: 214.27
Elemental Analysis: C, 72.87; H, 6.59; N, 13.07; O, 7.47
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Synonym: Fadolmidine
IUPAC/Chemical Name: 3-(Imidazol-4-ylmethyl)-5-indanol
InChi Key: VTZPAJGVRWKMAG-UHFFFAOYSA-N
InChi Code: InChI=1S/C13H14N2O/c16-12-4-3-9-1-2-10(13(9)6-12)5-11-7-14-8-15-11/h3-4,6-8,10,16H,1-2,5H2,(H,14,15)
SMILES Code: Oc1ccc2CCC(Cc3c[nH]cn3)c2c1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 214.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Berg T. Angiotensin AT1 - α2C-Adrenoceptor Interaction Disturbs α2A-auto-Inhibition of Catecholamine Release in Hypertensive Rats. Front Neurol. 2013 Jun 10;4:70. doi: 10.3389/fneur.2013.00070. PubMed PMID: 23772221; PubMed Central PMCID: PMC3677154.
2: Wei H, Pertovaara A. Regulation of neuropathic hypersensitivity by α(2) -adrenoceptors in the pontine A7 cell group. Basic Clin Pharmacol Toxicol. 2013 Feb;112(2):90-5. doi: 10.1111/j.1742-7843.2012.00930.x. Epub 2012 Sep 25. PubMed PMID: 22900496.
3: Chan AK, Cheung CW, Chong YK. Alpha-2 agonists in acute pain management. Expert Opin Pharmacother. 2010 Dec;11(17):2849-68. doi: 10.1517/14656566.2010.511613. Epub 2010 Aug 13. Review. PubMed PMID: 20707597.
4: Leino T, Viitamaa T, Haapalinna A, Lehtimäki J, Virtanen R. Pharmacological profile of intrathecal fadolmidine, a alpha2-adrenoceptor agonist, in rodent models. Naunyn Schmiedebergs Arch Pharmacol. 2009 Dec;380(6):539-50. doi: 10.1007/s00210-009-0460-6. Epub 2009 Oct 14. PubMed PMID: 19826791.
5: Lehtimäki J, Leino T, Koivisto A, Viitamaa T, Lehtimäki T, Haapalinna A, Kuokkanen K, Virtanen R. In vitro and in vivo profiling of fadolmidine, a novel potent alpha(2)-adrenoceptor agonist with local mode of action. Eur J Pharmacol. 2008 Dec 3;599(1-3):65-71. doi: 10.1016/j.ejphar.2008.10.003. Epub 2008 Oct 9. PubMed PMID: 18930723.
