WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 463558
CAS#: unknown
Description: OptoGluNAM4.1 is a novel negative allosteric modulator (NAM) of mGlu4, being isomerized with blue-light/dark cycles with fast relaxation.
MedKoo Cat#: 463558
Name: OptoGluNAM4.1
CAS#: unknown
Chemical Formula: C27H34ClN5O3
Exact Mass: 511.235
Molecular Weight: 512.051
Elemental Analysis: C, 63.33; H, 6.69; Cl, 6.92; N, 13.68; O, 9.37
This product is not in stock, which may be available by custom synthesis.
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Synonym: OptoGluNAM4.1;
IUPAC/Chemical Name: (2R,4S)-4-((E)-4-((4-((E)-(4-((2-chloroethyl)(ethyl)amino)phenyl)diazenyl)phenyl)(ethyl)amino)but-2-en-1-yl)-5-oxopyrrolidine-2-carboxylic acid
InChi Key: HNQKQKREAUMXOT-HWPVFFFUSA-N
InChi Code: InChI=1S/C27H34ClN5O3/c1-3-32(17-6-5-7-20-19-25(27(35)36)29-26(20)34)23-12-8-21(9-13-23)30-31-22-10-14-24(15-11-22)33(4-2)18-16-28/h5-6,8-15,20,25H,3-4,7,16-19H2,1-2H3,(H,29,34)(H,35,36)/b6-5+,31-30+/t20-,25+/m0/s1
SMILES Code: O=C([C@@H](C[C@@H]1C/C=C/CN(C2=CC=C(/N=N/C3=CC=C(N(CCCl)CC)C=C3)C=C2)CC)NC1=O)O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 512.051 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Bossi S, Helleringer R, Galante M, Monlleó E, Trapero A, Rovira X, Daniel H, Llebaria A, McLean H. A Light-Controlled Allosteric Modulator Unveils a Role for mGlu4 Receptors During Early Stages of Ischemia in the Rodent Cerebellar Cortex. Front Cell Neurosci. 2018 Nov 27;12:449. doi: 10.3389/fncel.2018.00449. PMID: 30542267; PMCID: PMC6277836.
2: Nicoletti F. Shedding Light on Metabotropic Glutamate Receptors. Cell Chem Biol. 2016 Aug 18;23(8):887-8. doi: 10.1016/j.chembiol.2016.08.001. PMID: 27541192.
3: Rovira X, Trapero A, Pittolo S, Zussy C, Faucherre A, Jopling C, Giraldo J, Pin JP, Gorostiza P, Goudet C, Llebaria A. OptoGluNAM4.1, a Photoswitchable Allosteric Antagonist for Real-Time Control of mGlu4 Receptor Activity. Cell Chem Biol. 2016 Aug 18;23(8):929-34. doi: 10.1016/j.chembiol.2016.06.013. Epub 2016 Jul 28. PMID: 27478159.
