Veratridine
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MedKoo CAT#: 412615

CAS#: 71-62-5

Description: Veratridine is a benzoate-cevane found in VERATRUM and Schoenocaulon. It activates SODIUM CHANNELS to stay open longer than normal.


Chemical Structure

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Veratridine
CAS# 71-62-5

Theoretical Analysis

MedKoo Cat#: 412615
Name: Veratridine
CAS#: 71-62-5
Chemical Formula: C36H51NO11
Exact Mass: 673.3462
Molecular Weight: 673.8
Elemental Analysis: C, 64.17; H, 7.63; N, 2.08; O, 26.12

Price and Availability

Size Price Availability Quantity
10.0mg USD 375.0 2 Weeks
25.0mg USD 669.0 2 Weeks
100.0mg USD 1610.0 2 Weeks
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Synonym: Veratridine; NSC7524; NSC-7524 NSC 7524

IUPAC/Chemical Name: 4,9-Epoxycevane-3beta,4alpha,12,14,16beta,17,20-heptol 3-veratrate

InChi Key: FVECELJHCSPHKY-BWFGFNOCSA-N

InChi Code: InChI=1S/C36H51NO11/c1-19-6-11-26-31(3,40)35(43)25(17-37(26)16-19)33(42)18-34-24(32(33,41)15-27(35)38)10-9-23-30(34,2)13-12-28(36(23,44)48-34)47-29(39)20-7-8-21(45-4)22(14-20)46-5/h7-8,14,19,23-28,38,40-44H,6,9-13,15-18H2,1-5H3/t19-,23-,24-,25-,26-,27-,28-,30-,31+,32+,33+,34?,35-,36+/m0/s1

SMILES Code: [H][C@@]12[C@](O3)(O)[C@@H](OC(C4=CC=C(OC)C(OC)=C4)=O)CC[C@]1(C)C53C[C@@]6(O)[C@]7([H])CN8C[C@@H](C)CC[C@]([H])8[C@@](C)(O)[C@@]7(O)[C@@H](O)C[C@@]6(O)[C@]5([H])CC2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 673.8 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Zhang XY, Bi RY, Zhang P, Gan YH. Veratridine modifies the gating of human voltage-gated sodium channel Nav1.7. Acta Pharmacol Sin. 2018 Nov;39(11):1716-1724. doi: 10.1038/s41401-018-0065-z. Epub 2018 Jun 27. PMID: 29950616; PMCID: PMC6289357.

2: Niitsu A, Egawa A, Ikeda K, Tachibana K, Fujiwara T. Veratridine binding to a transmembrane helix of sodium channel Nav1.4 determined by solid- state NMR. Bioorg Med Chem. 2018 Nov 15;26(21):5644-5653. doi: 10.1016/j.bmc.2018.10.012. Epub 2018 Oct 17. PMID: 30389410.

3: Wermelskirchen D, Wilffert B, Peters T. Veratridine-induced intoxication: an in vitro model for the characterization of anti-ischemic compounds? J Basic Clin Physiol Pharmacol. 1992 Oct-Dec;3(4):293-321. doi: 10.1515/jbcpp.1992.3.4.293. PMID: 1285006.

4: Sutro JB. Kinetics of veratridine action on Na channels of skeletal muscle. J Gen Physiol. 1986 Jan;87(1):1-24. doi: 10.1085/jgp.87.1.1. PMID: 2419478; PMCID: PMC2217133.

5: Ulbricht W. Effects of veratridine on sodium currents and fluxes. Rev Physiol Biochem Pharmacol. 1998;133:1-54. doi: 10.1007/BFb0000612. PMID: 9600010.

6: Tsukamoto T, Chiba Y, Nakazaki A, Ishikawa Y, Nakane Y, Cho Y, Yotsu- Yamashita M, Nishikawa T, Wakamori M, Konoki K. Inhibition of veratridine- induced delayed inactivation of the voltage-sensitive sodium channel by synthetic analogs of crambescin B. Bioorg Med Chem Lett. 2017 Mar 1;27(5):1247-1251. doi: 10.1016/j.bmcl.2017.01.054. Epub 2017 Jan 19. PMID: 28143690.

7: Kratholm NM, Jensen PS, Kringelholt S, Simonsen U, Bek T. Activation of Veratridine Sensitive Sodium Channels, But not Electrical Field Stimulation, Dilates Porcine Retinal Arterioles with Preserved Perivascular Tissue. Curr Eye Res. 2017 Nov;42(11):1497-1502. doi: 10.1080/02713683.2017.1337156. Epub 2017 Sep 14. PMID: 28910154.

8: Ito S, Nakazato Y, Ohga A. The effect of veratridine on the release of catecholamines from the perfused adrenal gland. Br J Pharmacol. 1979 Feb;65(2):319-30. doi: 10.1111/j.1476-5381.1979.tb07833.x. PMID: 760905; PMCID: PMC1668614.

9: Verheugen JA, Oortgiesen M, Vijverberg HP. Veratridine blocks voltage-gated potassium current in human T lymphocytes and in mouse neuroblastoma cells. J Membr Biol. 1994 Feb;137(3):205-14. doi: 10.1007/BF00232589. PMID: 8182730.

10: Jacobson I, Hamberger A. Veratridine-induced release in vivo and in vitro of amino acids in the rabbit olfactory bulb. Brain Res. 1984 May 7;299(1):103-12. doi: 10.1016/0006-8993(84)90792-3. PMID: 6144366.