Sanfetrinem sodium

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 575216

CAS#: 141611-76-9

Description: Sanfetrinem sodium is the first member of tricyclic beta-lactams (trinems) which can be administered orally as a hexatil ester and acts as an antibiotic.


Chemical Structure

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Sanfetrinem sodium
CAS# 141611-76-9

Theoretical Analysis

MedKoo Cat#: 575216
Name: Sanfetrinem sodium
CAS#: 141611-76-9
Chemical Formula: C14H18NNaO5
Exact Mass: 303.1083
Molecular Weight: 303.29
Elemental Analysis: C, 55.44; H, 5.98; N, 4.62; Na, 7.58; O, 26.38

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: GV 104326B; Sanfetrinem sodium

IUPAC/Chemical Name: Azeto(2,1-a)isoindole-4-carboxylic acid, 1,2,5,6,7,8,8a,8b-octahydro-1-(1-hydroxyethyl)-5-methoxy-2-oxo-, sodium salt, (1S-(1alpha(S(sup *)),5alpha,8aalpha,8balpha))-

InChi Key: YXEMRWDSRDEZLB-KOKFPPFCSA-M

InChi Code: InChI=1S/C14H19NO5.Na/c1-6(16)9-11-7-4-3-5-8(20-2)10(7)12(14(18)19)15(11)13(9)17;/h6-9,11,16H,3-5H2,1-2H3,(H,18,19);/q;+1/p-1/t6-,7+,8+,9-,11-;/m1./s1

SMILES Code: [Na+].CO[C@H]1CCC[C@@H]2[C@@H]3[C@@H]([C@@H](C)O)C(=O)N3C(=C12)C(=O)[O-]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 303.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Babini GS, Yuan M, Livermore DM. Interactions of beta-lactamases with sanfetrinem (GV 104326) compared to those with imipenem and with oral beta-lactams. Antimicrob Agents Chemother. 1998 May;42(5):1168-75. PubMed PMID: 9593145; PubMed Central PMCID: PMC105767.

2: Fasoli HJ, Frau J, Fenollar-Ferrer C, Muñoz F, Donoso J. Molecular modeling and chemical reactivity of sanfetrinem and derivatives. J Phys Chem B. 2005 May 19;109(19):9780-6. PubMed PMID: 16852178.

3: Spangler SK, Jacobs MR, Appelbaum PC. MIC and time-kill studies of antipneumococcal activity of GV 118819X (sanfetrinem) compared with those of other agents. Antimicrob Agents Chemother. 1997 Jan;41(1):148-55. PubMed PMID: 8980771; PubMed Central PMCID: PMC163676.

4: Cuffini AM, Tullio V, Bonino A, Allocco A, Palarchio AI, Carlone NA. Entry of sanfetrinem into human polymorphonuclear granulocytes and its cell-associated activity against intracellular, penicillin-resistant Streptococcus pneumoniae. Antimicrob Agents Chemother. 1998 Jul;42(7):1745-50. PubMed PMID: 9661015; PubMed Central PMCID: PMC105677.

5: Wieczorek P, Sacha PT, Leszczyńska K, Jakoniuk P, Zalewska M. [Sanfetrinem, the member of trinems--in vitro activity against Klebsiella pneumoniae producing ESBL]. Med Dosw Mikrobiol. 2006;58(1):27-32. Polish. PubMed PMID: 16871970.