Oxaflozane (free base)

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MedKoo CAT#: 412584

CAS#: 26629-87-8 (free base)

Description: Oxaflozane is a non-tricyclic antidepressant with serotoninergic action. In animals, oxaflozane has anti-cataleptic and anti-aggressive action with weak potentiation of stereotypes provoked by amphetamine. Oxaflozane was developed by Solvay Pharma and marketed in France under tradename Conflictan. The drug was discontinued in 2004.

Chemical Structure

Oxaflozane (free base)
CAS# 26629-87-8 (free base)

Theoretical Analysis

MedKoo Cat#: 412584
Name: Oxaflozane (free base)
CAS#: 26629-87-8 (free base)
Chemical Formula: C14H18F3NO
Exact Mass: 273.134
Molecular Weight: 273.29
Elemental Analysis: Chemical Formula: Exact Mass: Molecular Weight: Elemental Analysis: C, 61.53; H, 6.64; F, 20.85; N, 5.13; O, 5.85

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
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Related CAS #: 26629-87-8 (free base)   26629-86-7 (HCl)  

Synonym: Oxaflozane; EINECS 247-855-8; Oxaflozanum

IUPAC/Chemical Name: 4-(1-Methylethyl)-2-(3-(trifluoromethyl)phenyl)morpholine


InChi Code: InChI=1S/C14H18F3NO/c1-10(2)18-6-7-19-13(9-18)11-4-3-5-12(8-11)14(15,16)17/h3-5,8,10,13H,6-7,9H2,1-2H3


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 273.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Constantin M, Pognat JF. Comparative study of oxaflozane urinary metabolism in man, the dog and the rat. Identification of the principal metabolites. Arzneimittelforschung. 1979;29(1):109-14. PMID: 582104.

2: Hache J, Duchene-Marullaz P, Streichenberger G. Profil pharmacologique d'un nouvel antidépresseur non tricyclique: l'oxaflozane (1.766 Cerm) [Pharmacological profile of a new non tricyclic antidepressant: oxaflozane (1,766 Cerm)]. Therapie. 1974 Jan-Feb;29(1):81-93. French. PMID: 4849381.

3: Rascol A, Maurel H, David J, Layani M. Premiers résultats cliniques d'un nouvel antidépresseur non tricyclique: "loxaflozane" (1766 cerm) [Preliminary clinical results of a new non tricyclic antidepressive drug: oxaflozane]. Therapie. 1974 Jan-Feb;29(1):95-9. French. PMID: 4603757.

4: Dutertre JP, Barbier P, Suc AL, Jonville AP, Autret E. Oxaflozane overdose in a child. J Toxicol Clin Toxicol. 1992;30(1):123-6. doi: 10.3109/15563659208994452. PMID: 1542141.

5: Cosnier D, Grimal J, Rispat G, Streichenberger G. Propriétés cardiovasculaires de ĺoxaflozane (1,766 CERM) nouvel antiddpresseur non tricyclique [Cardiovascular properties of oxaflozane (1,766 CERM), a new non- tricyclic antidepressive]. Therapie. 1975 Jul-Aug;(4):539-54. French. PMID: 1209529.

6: Denber HC. Trials with drugs outside the United States. Dis Nerv Syst. 1974 Jul;35(7 Pt. 2):8-9. PMID: 17894094.