WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 412583
CAS#: 26629-86-7 (HCl)
Description: Oxaflozane hydrochloride is the salt form of Oxaflozane (free base), a non-tricyclic antidepressant with serotoninergic action. In animals, oxaflozane has anti-cataleptic and anti-aggressive action with weak potentiation of stereotypes provoked by amphetamine. Oxaflozane was developed by Solvay Pharma and marketed in France under tradename Conflictan. The drug was discontinued in 2004.
MedKoo Cat#: 412583
Name: Oxaflozane hydrochloride
CAS#: 26629-86-7 (HCl)
Chemical Formula: C14H19ClF3NO
Molecular Weight: 309.76
Elemental Analysis: C, 54.29; H, 6.18; Cl, 11.44; F, 18.40; N, 4.52; O, 5.17
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Synonym: Oxaflozane hydrochloride; CERM1766; CERM-1766; CERM 1766
IUPAC/Chemical Name: 4-(Isopropyl)-2-(3-(trifluoromethyl)phenyl)morpholine hydrochloride
InChi Key: XYYSVSLSSDHEGA-UHFFFAOYSA-N
InChi Code: InChI=1S/C14H18F3NO.ClH/c1-10(2)18-6-7-19-13(9-18)11-4-3-5-12(8-11)14(15,16)17;/h3-5,8,10,13H,6-7,9H2,1-2H3;1H
SMILES Code: FC(C1=CC(C2CN(C(C)C)CCO2)=CC=C1)(F)F.[H]Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 309.76 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Constantin M, Pognat JF. Comparative study of oxaflozane urinary metabolism in man, the dog and the rat. Identification of the principal metabolites. Arzneimittelforschung. 1979;29(1):109-14. PMID: 582104.
2: Dutertre JP, Barbier P, Suc AL, Jonville AP, Autret E. Oxaflozane overdose in a child. J Toxicol Clin Toxicol. 1992;30(1):123-6. doi: 10.3109/15563659208994452. PMID: 1542141.
3: Hache J, Duchene-Marullaz P, Streichenberger G. Profil pharmacologique d'un nouvel antidépresseur non tricyclique: l'oxaflozane (1.766 Cerm) [Pharmacological profile of a new non tricyclic antidepressant: oxaflozane (1,766 Cerm)]. Therapie. 1974 Jan-Feb;29(1):81-93. French. PMID: 4849381.
4: Rascol A, Maurel H, David J, Layani M. Premiers résultats cliniques d'un nouvel antidépresseur non tricyclique: "loxaflozane" (1766 cerm) [Preliminary clinical results of a new non tricyclic antidepressive drug: oxaflozane]. Therapie. 1974 Jan-Feb;29(1):95-9. French. PMID: 4603757.
5: Cosnier D, Grimal J, Rispat G, Streichenberger G. Propriétés cardiovasculaires de ĺoxaflozane (1,766 CERM) nouvel antiddpresseur non tricyclique [Cardiovascular properties of oxaflozane (1,766 CERM), a new non- tricyclic antidepressive]. Therapie. 1975 Jul-Aug;(4):539-54. French. PMID: 1209529.
6: Denber HC. Trials with drugs outside the United States. Dis Nerv Syst. 1974 Jul;35(7 Pt. 2):8-9. PMID: 17894094.