WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 575196

CAS#: 866598-45-0

Description: AZD-2207 is a cannabinoid receptor CB1 antagonist and highly lipophilic compound for the treatment of type 2 diabetes mellitus and obesity.

Chemical Structure

CAS# 866598-45-0

Theoretical Analysis

MedKoo Cat#: 575196
Name: AZD-2207
CAS#: 866598-45-0
Chemical Formula: C25H25Cl2F3N4O4S
Exact Mass: 604.0926
Molecular Weight: 605.4542
Elemental Analysis: C, 49.59; H, 4.16; Cl, 11.71; F, 9.41; N, 9.25; O, 10.57; S, 5.30

Price and Availability

Size Price Availability Quantity
1.0mg USD 150.0 Ready to Ship
5.0mg USD 250.0 Ready to Ship
10.0mg USD 450.0 Ready to Ship
25.0mg USD 750.0 Ready to Ship
50.0mg USD 1350.0 Ready to Ship
100.0mg USD 2350.0 Ready to Ship
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Synonym: AZD-2207; AZD2207; AZD 2207

IUPAC/Chemical Name: 1-Propanesulfonic acid, 3,3,3-trifluoro-, 4-(2-(2,4-dichlorophenyl)-5-methyl-4-((1-piperidinylamino)carbonyl)-1H-imidazol-1-yl)phenyl ester


InChi Code: InChI=1S/C25H25Cl2F3N4O4S/c1-16-22(24(35)32-33-12-3-2-4-13-33)31-23(20-10-5-17(26)15-21(20)27)34(16)18-6-8-19(9-7-18)38-39(36,37)14-11-25(28,29)30/h5-10,15H,2-4,11-14H2,1H3,(H,32,35)

SMILES Code: Cc1c(nc(c2ccc(Cl)cc2Cl)n1c3ccc(OS(=O)(=O)CCC(F)(F)F)cc3)C(=O)NN4CCCCC4

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Biological target: AZD-2207 is a cannabinoid receptor CB1 antagonist.
In vitro activity: TBD
In vivo activity: TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 605.4542 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: TBD
In vitro protocol: TBD
In vivo protocol: TBD

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1. Tannergren C, Karlsson E, Sigfridsson K, Lindfors L, Ku A, Polentarutti B, Carlert S. Biopharmaceutic Profiling of Salts to Improve Absorption of Poorly Soluble Basic Drugs. J Pharm Sci. 2016 Nov;105(11):3314-3323. doi: 10.1016/j.xphs.2016.07.016. Epub 2016 Sep 13. PMID: 27637320.

2. Kourentas A, Vertzoni M, Barmpatsalou V, Augustijns P, Beato S, Butler J, Holm R, Ouwerkerk N, Rosenberg J, Tajiri T, Tannergren C, Symillides M, Reppas C. The BioGIT System: a Valuable In Vitro Tool to Assess the Impact of Dose and Formulation on Early Exposure to Low Solubility Drugs After Oral Administration. AAPS J. 2018 May 24;20(4):71. doi: 10.1208/s12248-018-0231-8. PMID: 29797293.