MTMox32E

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 463486

CAS#: unknown

Description: MTMox32E is a novel Mithramycin A (MTM) 2'-oxime (MTMox) conjugate, displaying an 11-fold increase in plasma exposure and improved efficacy in an Ewing sarcoma xenograft.

Chemical Structure

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MTMox32E
CAS# unknown
Instruction

Theoretical Analysis

MedKoo Cat#: 463486
Name: MTMox32E
CAS#: unknown
Chemical Formula: C75H100N4O28
Exact Mass: 1,504.65
Molecular Weight: 1,505.625
Elemental Analysis: C, 59.83; H, 6.69; N, 3.72; O, 29.75

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: MTMox32E; MTMox-32E; MTMox 32E;

IUPAC/Chemical Name: methyl (2-((((1S,3R,4R,E)-1-((2S,3S)-3-(((2S,4R,5R,6R)-4-(((2S,4R,5S,6R)-4-(((2S,4S,5R,6R)-4,5-dihydroxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-7-(((2S,4R,5R,6R)-4-(((2S,4R,5S,6R)-4,5-dihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-5,10-dihydroxy-6-methyl-4-oxo-1,2,3,4-tetrahydroanthracen-2-yl)-3,4-dihydroxy-1-methoxypentan-2-ylidene)amino)oxy)acetyl)-L-phenylalanyl-L-tryptophanate

InChi Key: FFTVRDGIUYWQPQ-SHWURPSFSA-N

InChi Code: InChI=1S/C75H100N4O28/c1-32-49(103-55-26-50(65(86)35(4)99-55)104-54-25-48(81)64(85)34(3)98-54)24-41-21-40-22-44(70(95-9)61(63(84)33(2)80)79-97-31-53(82)77-46(20-39-16-12-11-13-17-39)73(92)78-47(74(93)96-10)23-42-30-76-45-19-15-14-18-43(42)45)71(69(90)60(40)68(89)59(41)62(32)83)107-57-28-51(66(87)37(6)101-57)105-56-27-52(67(88)36(5)100-56)106-58-29-75(8,94)72(91)38(7)102-58/h11-19,21,24,30,33-38,44,46-48,50-52,54-58,63-67,70-72,76,80-81,83-89,91,94H,20,22-23,25-29,31H2,1-10H3,(H,77,82)(H,78,92)/b79-61+/t33-,34-,35-,36-,37-,38-,44+,46+,47+,48-,50-,51-,52-,54+,55+,56+,57+,58+,63+,64-,65-,66-,67+,70+,71+,72-,75+/m1/s1

SMILES Code: O=C(OC)[C@H](CC1=CNC2=C1C=CC=C2)NC([C@H](CC3=CC=CC=C3)NC(CO/N=C([C@@H](O)[C@H](O)C)/[C@H]([C@@H]([C@@H]4O[C@H]5C[C@@H](O[C@H]6C[C@@H](O[C@H]7C[C@](C)(O)[C@H](O)[C@@H](C)O7)[C@@H](O)[C@@H](C)O6)[C@H](O)[C@@H](C)O5)CC8=C(C(O)=C9C(O)=C(C)C(O[C@H]%10C[C@@H](O[C@H]%11C[C@@H](O)[C@H](O)[C@@H](C)O%11)[C@H](O)[C@@H](C)O%10)=CC9=C8)C4=O)OC)=O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 1,505.63 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Liu Y, Eckenrode JM, Zhang Y, Zhang J, Hayden RC, Kyomuhangi A, Ponomareva LV, Cui Z, Rohr J, Tsodikov OV, Van Lanen SG, Shaaban KA, Leggas M, Thorson JS. Mithramycin 2'-Oximes with Improved Selectivity, Pharmacokinetics, and Ewing Sarcoma Antitumor Efficacy. J Med Chem. 2020 Nov 25;63(22):14067-14086. doi: 10.1021/acs.jmedchem.0c01526. Epub 2020 Nov 16. PMID: 33191745.