WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 463464
CAS#: unknown
Description: ID33 is a Potent Tubulin Polymerization Inhibitor. ID33 showed excellent aqueous solubility and favorable Log P value and displayed noteworthily low nanomolar potency against a variety of tumor cells, including those taxol-resistant ones. ID33 inhibited tubulin polymerization, disrupted cellular microtubule networks by targeting the colchicine site, and promoted HepG2 cell cycle arrest and cell apoptosis. In the HepG2 xenograft mouse model.
MedKoo Cat#: 463464
Name: ID33
CAS#: unknown
Chemical Formula: C23H31Cl2N5O3
Exact Mass: 495.1804
Molecular Weight: 496.433
Elemental Analysis: C, 55.65; H, 6.29; Cl, 14.28; N, 14.11; O, 9.67
This product is not in stock, which may be available by custom synthesis.
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Synonym: ID33; ID 33; ID-33;
IUPAC/Chemical Name: 7-(3-aminopropoxy)-6-ethoxy-N-(6-ethoxypyridin-2-yl)-1-methyl-1,4-dihydroindeno[1,2-c]pyrazol-3-amine dihydrochloride
InChi Key: QUKLDSQNXVICSW-UHFFFAOYSA-N
InChi Code: InChI=1S/C23H29N5O3.2ClH/c1-4-29-18-13-15-12-17-22(16(15)14-19(18)31-11-7-10-24)28(3)27-23(17)26-20-8-6-9-21(25-20)30-5-2;;/h6,8-9,13-14H,4-5,7,10-12,24H2,1-3H3,(H,25,26,27);2*1H
SMILES Code: CN1N=C(NC2=NC(OCC)=CC=C2)C3=C1C4=C(C=C(OCC)C(OCCCN)=C4)C3.[H]Cl.[H]Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 496.433 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Cui YJ, Liu C, Ma CC, Ji YT, Yao YL, Tang LQ, Zhang CM, Wu JD, Liu ZP. SAR Investigation and Discovery of Water-Soluble 1-Methyl-1,4-dihydroindeno[1,2-c]pyrazoles as Potent Tubulin Polymerization Inhibitors. J Med Chem. 2020 Nov 17. doi: 10.1021/acs.jmedchem.0c01345. Epub ahead of print. PMID: 33201714.
