Fusidate Sodium | CAS# 751-94-0 (Na+) | antibiotic

Fusidate Sodium
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 412555

CAS#: 751-94-0 (Na+)

Description: Fusidate Sodium is an antibiotic isolated from the fermentation broth of Fusidium coccineum. (From Merck Index, 11th ed) It acts by inhibiting translocation during protein synthesis.

Chemical Structure

Fusidate Sodium

CAS# 751-94-0 (Na+)

Instruction

Theoretical Analysis

MedKoo Cat#: 412555
Name: Fusidate Sodium
CAS#: 751-94-0 (Na+)
Chemical Formula: C31H47NaO6
Exact Mass: 0.00
Molecular Weight: 538.700
Elemental Analysis: C, 69.12; H, 8.79; Na, 4.27; O, 17.82

Price and Availability

Size	Price	Availability
1g	USD 406	2 Weeks
5g	USD 1166	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: Fusidate Sodium; CEM102; CEM 102; CEM-102

IUPAC/Chemical Name: sodium (Z)-2-((3R,4S,5S,8S,9S,10S,11R,13R,14S,16S)-16-acetoxy-3,11-dihydroxy-4,8,10,14-tetramethylhexadecahydro-17H-cyclopenta[a]phenanthren-17-ylidene)-6-methylhept-5-enoate

InChi Key: HJHVQCXHVMGZNC-JCJNLNMISA-M

InChi Code: InChI=1S/C31H48O6.Na/c1-17(2)9-8-10-20(28(35)36)26-22-15-24(34)27-29(5)13-12-23(33)18(3)21(29)11-14-30(27,6)31(22,7)16-25(26)37-19(4)32;/h9,18,21-25,27,33-34H,8,10-16H2,1-7H3,(H,35,36);/q;+1/p-1/b26-20-;/t18-,21-,22-,23+,24+,25-,27-,29-,30-,31-;/m0./s1

SMILES Code: C[C@@H]1[C@@H](CC[C@]2([C@H]1CC[C@]3([C@H]2[C@@H](C[C@H]4/C([C@@H](OC(C)=O)C[C@]34C)=C(C([O-])=O)\CC/C=C(C)\C)O)C)C)O.[Na+]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 538.70 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Mishriky J, Balassone J, Bashour Z, Kaur S, Raman V, Getachew R, Osman N, Guidone D, Chan V, Little PJ. An Investigation of Sodium Fusidate and Recombinant Cytochrome P450 Enzymes Inhibition In-Vitro. Drug Metab Lett. 2016;10(3):180-186. doi: 10.2174/1872312810666160607015045. PMID: 27280598.

2: Kim DW, Kim KS, Seo YG, Lee BJ, Park YJ, Youn YS, Kim JO, Yong CS, Jin SG, Choi HG. Novel sodium fusidate-loaded film-forming hydrogel with easy application and excellent wound healing. Int J Pharm. 2015 Nov 10;495(1):67-74. doi: 10.1016/j.ijpharm.2015.08.082. Epub 2015 Sep 4. PMID: 26325319.

3: Mulla Z, Edwards M, Nicholson JW. Release of sodium fusidate from glass- ionomer dental cement. J Mater Sci Mater Med. 2010 Jun;21(6):1997-2000. doi: 10.1007/s10856-010-4060-2. Epub 2010 Apr 8. PMID: 20376540.

4: Sodium fusidate. S Afr Med J. 1969 Dec 27;43(51):1537. PMID: 5372049.

5: Eid AM, Istateyeh I, Salhi N, Istateyeh T. Antibacterial Activity of Fusidic Acid and Sodium Fusidate Nanoparticles Incorporated in Pine Oil Nanoemulgel. Int J Nanomedicine. 2019 Dec 2;14:9411-9421. doi: 10.2147/IJN.S229557. PMID: 31819440; PMCID: PMC6898994.

6: Jin SG, Kim KS, Kim DW, Kim DS, Seo YG, Go TG, Youn YS, Kim JO, Yong CS, Choi HG. Development of a novel sodium fusidate-loaded triple polymer hydrogel wound dressing: Mechanical properties and effects on wound repair. Int J Pharm. 2016 Jan 30;497(1-2):114-22. doi: 10.1016/j.ijpharm.2015.12.007. Epub 2015 Dec 4. PMID: 26657270.

7: Carey MC, Small DM. Micellar properties of sodium fusidate, a steroid antibiotic structurally resembling the bile salts. J Lipid Res. 1971 Sep;12(5):604-13. PMID: 5098396.

8: Morley PA, Munot LD. A comparison of sodium fusidate ointment and mupirocin ointment in superficial skin sepsis. Curr Med Res Opin. 1988;11(2):142-8. doi: 10.1185/03007998809110457. PMID: 3146465.

9: Somerville DA, Noble WC, White PM, Seville RH, Savin JA. Sodium fusidate in the treatment of erythrasma. Br J Dermatol. 1971 Nov;85(5):450-3. doi: 10.1111/j.1365-2133.1971.tb14051.x. PMID: 4943603.

10: Sesso R, Parisio K, Dalboni A, Rabelo T, Barbosa D, Cendoroglo M, Pignatari A, Draibe S, Ajzen H. Effect of sodium fusidate and ofloxacin on Staphylococcus aureus colonization and infection in patients on continuous ambulatory peritoneal dialysis. Clin Nephrol. 1994 Jun;41(6):370-6. PMID: 8076441.

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