CAY10773
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 463461

CAS#: 1648546-79-5

Description: CAY10773 is a derivative of the ferroptosis inducer sorafenib. It selectively inhibits proliferation of BEL-7402, MGC803, and T24 bladder cancer cells over non-cancerous HCV-29 cells. CAY10773 induces apoptosis in T24 cells when used at concentrations ranging from 2 to 6 µM but induces ferroptosis at concentrations greater than or equal to 6 µM with 10 hour or longer incubation times. It increases the production of reactive oxygen species (ROS) and decreases the mitochondrial membrane potential in T24 cells. CAY10773 also induces autophagy with incubation times longer than eight hours.

Chemical Structure

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CAY10773
CAS# 1648546-79-5
Instruction

Theoretical Analysis

MedKoo Cat#: 463461
Name: CAY10773
CAS#: 1648546-79-5
Chemical Formula: C22H17Cl2N5O
Exact Mass: 437.08
Molecular Weight: 438.312
Elemental Analysis: C, 60.29; H, 3.91; Cl, 16.18; N, 15.98; O, 3.65

Price and Availability

Size Price Availability Quantity
1mg USD 265 2 Weeks
5mg USD 650 2 Weeks
10mg USD 1050 2 Weeks
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Synonym: CAY10773; CAY 10773; CAY-10773;

IUPAC/Chemical Name: 1-(3,4-dichlorophenyl)-3-(3-((quinazolin-4-ylamino)methyl)phenyl)urea

InChi Key: UFOVWAAXBJCADF-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H17Cl2N5O/c23-18-9-8-16(11-19(18)24)29-22(30)28-15-5-3-4-14(10-15)12-25-21-17-6-1-2-7-20(17)26-13-27-21/h1-11,13H,12H2,(H,25,26,27)(H2,28,29,30)

SMILES Code: ClC1=CC(N([H])C(N([H])C2=CC=CC(CN([H])C3=C4C(C=CC=C4)=NC=N3)=C2)=O)=CC=C1Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 438.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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