Cephradine dihydrate

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MedKoo CAT#: 412534

CAS#: 31828-50-9 (dihydrate)

Description: Cephradine dihydrate is the hydrate form of Cephradine (free base), a semi-synthetic cephalosporin antibiotic. Cefradin inhibits the last stage of bacterial cell wall synthesis by binding to certain penicillin-binding proteins which results in cell lysis. Cell lysis is mediated by bacterial cell wall autolytic enzymes. Cefradin may interfere with autolysin inhibitors.

Chemical Structure

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Cephradine dihydrate
CAS# 31828-50-9 (dihydrate)
Instruction

Theoretical Analysis

MedKoo Cat#: 412534
Name: Cephradine dihydrate
CAS#: 31828-50-9 (dihydrate)
Chemical Formula: C16H21N3O5S
Exact Mass: 367.12
Molecular Weight: 367.420
Elemental Analysis: C, 52.30; H, 5.76; N, 11.44; O, 21.77; S, 8.73

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 31828-50-9 (dihydrate)   38821-53-3 (free base)   57584-26-6 (sodium)  

Synonym: Cephradine dihydrate; Sefril hydrate; Velosef hydrate; Cefradin hydrate; UNII-56PPJ9MMPE

IUPAC/Chemical Name: 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(2-amino-2-(1,4-cyclohexadien-1-yl)acetamido)-3-methyl-8-oxo-, hydrate, D-

InChi Key: VHNPSPMQGXQSET-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H19N3O4S.H2O/c1-8-7-24-15-11(14(21)19(15)12(8)16(22)23)18-13(20)10(17)9-5-3-2-4-6-9;/h2-3,6,10-11,15H,4-5,7,17H2,1H3,(H,18,20)(H,22,23);1H2

SMILES Code: O=C(C(N12)=C(C)CSC2C(NC(C(N)C3=CCC=CC3)=O)C1=O)O.[H]O[H]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 367.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Butt A, Jabeen S, Nisar N, Islam A, Gull N, Iqbal SS, Khan SM, Yameen B. Controlled release of cephradine by biopolymers based target specific crosslinked hydrogels. Int J Biol Macromol. 2019 Jan;121:104-112. doi: 10.1016/j.ijbiomac.2018.10.018. Epub 2018 Oct 3. PMID: 30291928.

2: Jahanfar S, Ng CJ, Teng CL. Antibiotics for mastitis in breastfeeding women. Cochrane Database Syst Rev. 2013 Feb 28;(2):CD005458. doi: 10.1002/14651858.CD005458.pub3. PMID: 23450563.

3: Arayne MS, Sultana N, Afzal M. Cephradine antacids interaction studies. Pak J Pharm Sci. 2007 Jul;20(3):179-84. PMID: 17545100.

4: Mashimo K. [Cefroxadine]. Jpn J Antibiot. 1982 Jun;35(6):1365-73. Japanese. PMID: 6752462.

5: Dallmann A, Ince I, Solodenko J, Meyer M, Willmann S, Eissing T, Hempel G. Physiologically Based Pharmacokinetic Modeling of Renally Cleared Drugs in Pregnant Women. Clin Pharmacokinet. 2017 Dec;56(12):1525-1541. doi: 10.1007/s40262-017-0538-0. PMID: 28391404.

6: Huang X, Xue J, Zhu Y. Computational design of cephradine synthase in a new scaffold identified from structural databases. Chem Commun (Camb). 2017 Jul 4;53(54):7604-7607. doi: 10.1039/c7cc02270k. PMID: 28639649.

7: van de Streek J, Rantanen J, Bond AD. Structures of cefradine dihydrate and cefaclor dihydrate from DFT-D calculations. Acta Crystallogr C. 2013 Nov;69(Pt 11):1229-33. doi: 10.1107/S0108270113026863. Epub 2013 Oct 19. PMID: 24192164.

8: Foster DR, Yee S, Bleske BE, Carver PL, Shea MJ, Menon SS, Ramachandran C, Welage LS, Amidon GL. Lack of interaction between the peptidomimetic substrates captopril and cephradine. J Clin Pharmacol. 2009 Mar;49(3):360-7. doi: 10.1177/0091270008329554. PMID: 19246733.

9: Wiles CM, Assem ES, Cohen SL, Fisher C. Cephradine-induced interstitial nephritis. Clin Exp Immunol. 1979 May;36(2):342-6. PMID: 89922; PMCID: PMC1537712.

10: Hutschenreiter G, Klippel KF. Cefradin in der Urologie [Cephradine in urology]. MMW Munch Med Wochenschr. 1977 Nov 25;119(47):1539-40. German. PMID: 414092.