S 1108
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MedKoo CAT#: 412504

CAS#: 147816-24-8

Description: S 1108 is an oral cephem antibiotic


Chemical Structure

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S 1108
CAS# 147816-24-8

Theoretical Analysis

MedKoo Cat#: 412504
Name: S 1108
CAS#: 147816-24-8
Chemical Formula: C23H32ClN5O9S2
Exact Mass: 621.13
Molecular Weight: 622.11
Elemental Analysis: C, 44.41; H, 5.18; Cl, 5.70; N, 11.26; O, 23.15; S, 10.31

Price and Availability

Size Price Availability Quantity
200.0mg USD 278.0 2 Weeks
1.0g USD 626.0 2 Weeks
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Synonym: S 1108; S1108; S-1108

IUPAC/Chemical Name: 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 3-(((aminocarbonyl)oxy)methyl)-7-((2-(2-amino-4-thiazolyl)-1-oxo-2-pentenyl)amino)-8-oxo-, (2,2-dimethyl-1-oxopropoxy)methyl ester,(6R-(6-alpha,7-beta(Z)))-, monohydrochloride, hydrate

InChi Key: LUXIJPQYUCFVAL-XRLCNELCSA-N

InChi Code: InChI=1S/C23H29N5O8S2.ClH.H2O/c1-5-6-12(13-9-38-21(24)26-13)16(29)27-14-17(30)28-15(11(7-34-22(25)33)8-37-18(14)28)19(31)35-10-36-20(32)23(2,3)4;;/h6,9,14,18H,5,7-8,10H2,1-4H3,(H2,24,26)(H2,25,33)(H,27,29);1H;1H2/b12-6-;;/t14-,18-;;/m1../s1

SMILES Code: O=C(C(N12)=C(COC(N)=O)CS[C@]2([H])[C@H](NC(/C(C3=CSC(N)=N3)=C\CC)=O)C1=O)OCOC(C(C)(C)C)=O.[H]Cl.[H]O[H]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 622.11 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Totsuka K, Shimizu K, Konishi M, Yamamoto S. Metabolism of S-1108, a new oral cephem antibiotic, and metabolic profiles of its metabolites in humans. Antimicrob Agents Chemother. 1992 Apr;36(4):757-61. doi: 10.1128/aac.36.4.757. PMID: 1503437; PMCID: PMC189391.

2: Mizojiri K, Futaguchi S, Norikura R, Katsuyama Y, Nagasaki T, Yoshimori T, Nakanishi M. Disposition of S-1108, a new oral cephem antibiotic, and metabolic fate of pivalic acid liberated from [pivaloyl-14C]S-1108 in rats and dogs. Antimicrob Agents Chemother. 1995 Jul;39(7):1445-53. doi: 10.1128/aac.39.7.1445. Erratum in: Antimicrob Agents Chemother. 1995 Oct;39(10):2373. PMID: 7492083; PMCID: PMC162760.

3: Fujii R, Abe T, Tajima T, Terashima I, Meguro H, Mori A, Sato H, Niino K, Sunakawa K, Yokota T, et al. [Pharmacokinetic and clinical studies of S-1108 in the pediatric field. Pediatric Study Group of S-1108]. Jpn J Antibiot. 1995 Jul;48(7):921-41. Japanese. PMID: 7563586.

4: Nakashima M, Uematsu T, Oguma T, Yoshida T, Mizojiri K, Matsuno S, Yamamoto S. Phase I clinical studies of S-1108: safety and pharmacokinetics in a multiple-administration study with special emphasis on the influence on carnitine body stores. Antimicrob Agents Chemother. 1992 Apr;36(4):762-8. doi: 10.1128/aac.36.4.762. Erratum in: Antimicrob Agents Chemother 1992 Jul;36(7):1587. PMID: 1503438; PMCID: PMC189394.

5: Kuno K, Ogawa A, Hayakawa F, Ito K, Kondo M, Okumura A, Natsume J. [Clinical studies on S-1108 in the field pediatrics]. Jpn J Antibiot. 1993 Nov;46(11):1017-24. Japanese. PMID: 8309064.

6: Tajima T, Kondo Y, Negishi S, Nishimura S, Yoshida A, Hagiwara N, Niimi R, Esaki E, Kaneko S, Abe T. [Pharmacokinetic, bacteriological and clinical studies on S-1108 in children]. Jpn J Antibiot. 1993 Nov;46(11):953-8. Japanese. PMID: 8309071.

7: Toyonaga Y, Ishihara T, Tezuka T, Sano T, Nakamura H. [Pharmacokinetic and clinical studies of S-1108 in the pediatric field]. Jpn J Antibiot. 1993 Nov;46(11):991-1002. Japanese. PMID: 8309075.

8: Takeda E, Ito M, Kuroda Y. [Clinical experience with S-1108 on bacterial infection in the pediatric field]. Jpn J Antibiot. 1993 Dec;46(12):1096-101. Japanese. PMID: 8107273.

9: Nakamura H, Iwai N, Miyazu M, Watanabe Y. [Laboratory and clinical evaluation of S-1108 in pediatric field]. Jpn J Antibiot. 1993 Nov;46(11):1003-16. Japanese. PMID: 8309063.

10: Motohiro T, Handa S, Yamada S, Oki S, Yoshinaga Y, Aramaki M, Oda K, Sakata Y, Kato H, Yamashita F, et al. [Basic and clinical studies on S-1108 in pediatric field]. Jpn J Antibiot. 1993 Dec;46(12):1122-44. Japanese. PMID: 8107277.

S 1108

200.0mg / USD 278.0