WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 463401
CAS#: 2378515-04-7
Description: E197 is a DOCK5 inhibitor. E197 can inhibit both mouse and human osteoclast activity. In particular, E197 prevented pathological bone loss in mice. Most interestingly, treatment with E197 did not affect osteoclast and osteoblast numbers and hence did not impair bone formation. E197 could represent a lead molecule to develop new antiosteoporotic drugs targeting the mechanism of osteoclast adhesion onto the bone.
MedKoo Cat#: 463401
Name: E197
CAS#: 2378515-04-7
Chemical Formula: C19H21ClN2O3S
Exact Mass: 392.0961
Molecular Weight: 392.898
Elemental Analysis: C, 58.08; H, 5.39; Cl, 9.02; N, 7.13; O, 12.22; S, 8.16
This product is not in stock, which may be available by custom synthesis.
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Synonym: E197; E 197; E-197;
IUPAC/Chemical Name: (4S,5R)-7-(4-chlorobenzyl)-4-hydroxy-2-phenyl-1-thia-2,7-diazaspiro[4.4]nonane 1,1-dioxide
InChi Key: KNPZNXSUFBUIGL-RBUKOAKNSA-N
InChi Code: InChI=1S/C19H21ClN2O3S/c20-16-8-6-15(7-9-16)12-21-11-10-19(14-21)18(23)13-22(26(19,24)25)17-4-2-1-3-5-17/h1-9,18,23H,10-14H2/t18-,19+/m0/s1
SMILES Code: O=S1(N(C2=CC=CC=C2)C[C@H](O)[C@@]13CN(CC4=CC=C(Cl)C=C4)CC3)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 392.898 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Mounier L, Morel A, Ferrandez Y, Morko J, Vääräniemi J, Gilardone M, Roche D, Cherfils J, Blangy A. Novel 2,7-Diazaspiro[4,4]nonane Derivatives to Inhibit Mouse and Human Osteoclast Activities and Prevent Bone Loss in Ovariectomized Mice without Affecting Bone Formation. J Med Chem. 2020 Nov 11. doi: 10.1021/acs.jmedchem.0c01201. Epub ahead of print. PMID: 33175535.
