Prolintane (free base)

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 412449

CAS#: 493-92-5 (free base)

Description: Prolintane (free base) is a stimulant and norepinephrine-dopamine reuptake inhibitor developed in the 1950s. It is the member of amphetamine and derivatives. It is closely related in chemical structure to other drugs such as pyrovalerone, MDPV, and propylhexedrine and it has a similar mechanism of action.

Chemical Structure

Prolintane (free base)
CAS# 493-92-5 (free base)

Theoretical Analysis

MedKoo Cat#: 412449
Name: Prolintane (free base)
CAS#: 493-92-5 (free base)
Chemical Formula: C15H23N
Exact Mass: 217.183
Molecular Weight: 217.36
Elemental Analysis: C, 82.89; H, 10.67; N, 6.44

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Related CAS #: 493-92-5 (free base)   1211-28-5 (HCl)  

Synonym: Prolintane (free base); BRN-0144260; BRN0144260; BRN 0144260

IUPAC/Chemical Name: 1-(1-phenylpentan-2-yl)pyrrolidine


InChi Code: InChI=1S/C15H23N/c1-2-8-15(16-11-6-7-12-16)13-14-9-4-3-5-10-14/h3-5,9-10,15H,2,6-8,11-13H2,1H3

SMILES Code: CCCC(N1CCCC1)Cc2ccccc2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 217.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

1: Kyle PB, Daley WP. Domestic abuse of the European rave drug prolintane. J Anal Toxicol. 2007 Sep;31(7):415-8. doi: 10.1093/jat/31.7.415. PMID: 17725890.

2: Martínez-Mir I, Catalán C, Palop V. Prolintane: a "masked" amphetamine. Ann Pharmacother. 1997 Feb;31(2):256. doi: 10.1177/106002809703100228. PMID: 9034438.

3: Gaulier JM, Canal M, Pradeille JL, Marquet P, Lachâtre G. Nouvelles drogues de « rave-parties » : ketamine et prolintane. Acta Clin Belg. 2002;57 Suppl 1:41-6. doi: 10.1179/acb.2002.076. PMID: 24862524.

4: Fuller RW, Snoddy HD. Effects of prolintane on 3,4-dihydroxyphenylacetic acid concentration in rat brain after spiperone treatment. Pharmacol Biochem Behav. 1979 Apr;10(4):561-3. doi: 10.1016/0091-3057(79)90233-8. PMID: 572552.

5: Payá B, Guisado JA, Vaz FJ, Crespo-Facorro B. Visual hallucinations induced by the combination of prolintane and diphenhydramine. Pharmacopsychiatry. 2002 Jan;35(1):24-5. doi: 10.1055/s-2002-19829. PMID: 11819155.

6: Souders CL 2nd, Davis RH, Qing H, Liang X, Febo M, Martyniuk CJ. The psychoactive cathinone derivative pyrovalerone alters locomotor activity and decreases dopamine receptor expression in zebrafish (Danio rerio). Brain Behav. 2019 Nov;9(11):e01420. doi: 10.1002/brb3.1420. Epub 2019 Oct 18. PMID: 31625691; PMCID: PMC6851804.

7: Rücker G, Neugebauer M, Zhong D. Synthese einiger Metaboliten und der Enantiomeren des Prolintans [Synthesis of metabolites and enantiomers of prolintane]. Arch Pharm (Weinheim). 1992 Jan;325(1):47-52. German. doi: 10.1002/ardp.19923250111. PMID: 1605711.

8: Gaulier JM, Canal M, Pradeille JL, Marquet P, Lachâtre G. Nouvelles drogues de "rave-parties": Kétamine et Prolintane [New drugs at "rave parties": ketamine and prolintane]. Acta Clin Belg. 2002;57 Suppl 1:41-6. French. PMID: 11974443.

9: Nicholson AN, Stone BM, Jones MM. Wakefullness and reduced rapid eye movement sleep: studies with prolintane and pemoline. Br J Clin Pharmacol. 1980 Nov;10(5):465-72. doi: 10.1111/j.1365-2125.1980.tb01790.x. PMID: 7437258; PMCID: PMC1430138.

10: Espartero AG, Pérez JA, Zapardiel A, Bermejo E, Hernández L. Direct determination of prolintane and its metabolite oxoprolintane in human urine by capillary zone electrophoresis and beta-cyclodextrin-modified micellar electrokinetic chromatography. J Chromatogr A. 1997 Aug 22;778(1-2):355-61. doi: 10.1016/s0021-9673(97)00478-0. PMID: 9299746.