Cationomycin

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 412448

CAS#: 80394-65-6

Description: Cationomycin is a polyether ionophore antibiotic produced by Actinomadura Nov. sp


Chemical Structure

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Cationomycin
CAS# 80394-65-6

Theoretical Analysis

MedKoo Cat#: 412448
Name: Cationomycin
CAS#: 80394-65-6
Chemical Formula: C45H70O15
Exact Mass: 850.4715
Molecular Weight: 851.04
Elemental Analysis: C, 63.51; H, 8.29; O, 28.20

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Cationomycin; BRN6263205; BRN-6263205; BRN 6263205

IUPAC/Chemical Name: 2-hydroxy-4-(9-hydroxy-2-((2S,2'R,2''S,3S,3'S,3''S,5'R,5''S)-5''-((S)-1-hydroxypropyl)-3-methoxy-2,3',3'',5''-tetramethyldodecahydro-[2,2':5',2''-terfuran]-5-yl)-2,3,8-trimethyl-1,6-dioxaspiro[4.5]decan-7-yl)-3-((2-hydroxy-4-methoxy-6-methylbenzoyl)oxy)-2-methylbutanoic acid

InChi Key: SGLQOFJJLQBZBE-MSFHLGAUSA-N

InChi Code: InChI=1S/C45H70O15/c1-13-32(48)41(7)19-24(4)37(59-41)31-15-23(3)38(55-31)44(10)34(54-12)18-35(58-44)43(9)25(5)20-45(60-43)21-29(47)26(6)30(57-45)17-33(42(8,52)40(50)51)56-39(49)36-22(2)14-27(53-11)16-28(36)46/h14,16,23-26,29-35,37-38,46-48,52H,13,15,17-21H2,1-12H3,(H,50,51)/t23-,24-,25?,26?,29?,30?,31+,32-,33?,34-,35?,37-,38+,41-,42?,43?,44-,45?/m0/s1

SMILES Code: CC[C@@H]([C@@]1(C[C@@H]([C@@H]([C@H]2C[C@@H]([C@H]([C@]3(OC(C4(OC5(CC(C(C(O5)CC(C(O)(C(O)=O)C)OC(c6c(O)cc(OC)cc6C)=O)C)O)CC4C)C)C[C@@H]3OC)C)O2)C)O1)C)C)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 851.04 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Gibot S, Jeminet G, Juillard J, Gumila C, Ancelin ML, Vial H, Delort AM. Cationomycin and monensin partition between serum proteins and erythrocyte membrane: consequences for Na+ and K+ transport and antimalarial activities. Arch Biochem Biophys. 1999 Mar 15;363(2):361-72. doi: 10.1006/abbi.1999.1101. PMID: 10068460.

2: Delort AM, Jeminet G, Sareth S, Riddle FG. Ionophore properties of cationomycin in large unilamellar vesicles studied by 23Na- and 39K-NMR. Chem Pharm Bull (Tokyo). 1998 Oct;46(10):1618-20. doi: 10.1248/cpb.46.1618. PMID: 9810697.

3: Nakamura G, Isono K. A new species of Actinomadura producing a polyether antibiotic, cationomycin. J Antibiot (Tokyo). 1983 Nov;36(11):1468-72. doi: 10.7164/antibiotics.36.1468. PMID: 6654756.

4: Gomez L, Jouany JP. Effects of lasalocid and cationomycin on the evolution of certain parameters in the blood plasma of sheep. Arch Tierernahr. 1994;46(3):283-93. doi: 10.1080/17450399409381778. PMID: 7619003.

5: Nakamura G, Kobayashi K, Sakurai T, Isono K. Cationomycin, a new polyether ionophore antibiotic produced by Actinomadura Nov. sp. J Antibiot (Tokyo). 1981 Nov;34(11):1513-4. doi: 10.7164/antibiotics.34.1513. PMID: 7319913.

6: Gomez L, Jouany JP, Lefaivre J. Influence of lasalocid, cationomycin and feeding frequency on the postprandial kinetics of some plasma parameters in the rumen vein, portal vein and mesenteric artery of sheep. Arch Tierernahr. 1995;48(4):357-66. doi: 10.1080/17450399509381855. PMID: 8585807.

7: Gomez L, Lallès JP, Bogaërt C, Poncet C. Kinetics of particulate and solute marker passage in sheep supplemented with cationomycin and lasalocid antibiotics. Comparisons among methods for calculating mean retention time. Reprod Nutr Dev. 1992;32(2):173-90. doi: 10.1051/rnd:19920210. PMID: 1388694.

8: Hillaire MC, Jouany JP, Gaboyard C, Jeminet G. In vitro study of the effect of different ionophore antibiotics and of certain derivatives on rumen fermentation and on protein nitrogen degradation. Reprod Nutr Dev. 1989;29(3):247-57. doi: 10.1051/rnd:19890302. PMID: 2590388.