Aculeacin A

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 463386

CAS#: 58814-86-1

Description: Aculeacin A is used to study mutations that lead to antibiotic resistance in Saccharomyces cerevisiae, the inhibition of Candida albicans and the morphogenetic transformation of Candida albicans when treated. Aculeacin A is a lipopeptide that inhibits β-glucan synthesis in yeasts. The inhibition is due to the selective blockage of glucan synthase. Aculeacin A, an amphophilic antibiotic, inhibits the biosynthesis of β−glucan by selective blockage of β(1→3) glucan synthase.

Chemical Structure

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Aculeacin A
CAS# 58814-86-1
Instruction

Theoretical Analysis

MedKoo Cat#: 463386
Name: Aculeacin A
CAS#: 58814-86-1
Chemical Formula: C51H82N8O17
Exact Mass: 1,078.58
Molecular Weight: 1,079.256
Elemental Analysis: C, 56.76; H, 7.66; N, 10.38; O, 25.20

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Aculeacin A; Aculeacin-A;

IUPAC/Chemical Name: N-((2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-20-((R)-3-amino-1-hydroxy-3-oxopropyl)-23-((1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl)-2,11,12,15-tetrahydroxy-6-((R)-1-hydroxyethyl)-16-methyl-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-9-yl)palmitamide

InChi Key: FBCLKBXYZRAXNA-PDIPHZEPSA-N

InChi Code: InChI=1S/C51H82N8O17/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-37(66)53-32-23-35(64)47(72)57-49(74)41-42(67)27(2)25-59(41)51(76)39(34(63)24-36(52)65)55-48(73)40(44(69)43(68)29-18-20-30(61)21-19-29)56-46(71)33-22-31(62)26-58(33)50(75)38(28(3)60)54-45(32)70/h18-21,27-28,31-35,38-44,47,60-64,67-69,72H,4-17,22-26H2,1-3H3,(H2,52,65)(H,53,66)(H,54,70)(H,55,73)(H,56,71)(H,57,74)/t27-,28+,31+,32-,33-,34+,35+,38-,39-,40-,41-,42-,43-,44-,47+/m0/s1

SMILES Code: CCCCCCCCCCCCCCCC(N[C@H]1C[C@H]([C@H](NC([C@@H]2[C@H]([C@H](CN2C([C@H]([C@@H](CC(N)=O)O)NC([C@H]([C@@H]([C@H](c3ccc(O)cc3)O)O)NC([C@@H]4C[C@H](CN4C([C@H]([C@H](O)C)NC1=O)=O)O)=O)=O)=O)C)O)=O)O)O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 1,079.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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8: Chen CN, Chen CJ, Liao CT, Lee CY. A probable aculeacin A acylase from the Ralstonia solanacearum GMI1000 is N-acyl-homoserine lactone acylase with quorum- quenching activity. BMC Microbiol. 2009 May 9;9:89. doi: 10.1186/1471-2180-9-89. PMID: 19426552; PMCID: PMC2686713.

9: Torres-Bacete J, Hormigo D, Stuart M, Arroyo M, Torres P, Castillón MP, Acebal C, García JL, de la Mata I. Newly discovered penicillin acylase activity of aculeacin A acylase from Actinoplanes utahensis. Appl Environ Microbiol. 2007 Aug;73(16):5378-81. doi: 10.1128/AEM.00452-07. Epub 2007 Jun 22. PMID: 17586674; PMCID: PMC1950969.

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