WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 412427
CAS#: 477-89-4
Description: Casimiroin is a quinone reductase 2 inhibitor; isolated from Casimiroa edulis.
MedKoo Cat#: 412427
Name: Casimiroin
CAS#: 477-89-4
Chemical Formula: C12H11NO4
Exact Mass: 233.0688
Molecular Weight: 233.22
Elemental Analysis: C, 61.80; H, 4.75; N, 6.01; O, 27.44
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Synonym: Casimiroin; UNII-1X2A1U6BH3
IUPAC/Chemical Name: 1,3-Dioxolo(4,5-h)quinolin-8(9H)-one, 6-methoxy-9-methyl-
InChi Key: DPXXJCMMMXZVSW-UHFFFAOYSA-N
InChi Code: InChI=1S/C12H11NO4/c1-13-10(14)5-9(15-2)7-3-4-8-12(11(7)13)17-6-16-8/h3-5H,6H2,1-2H3
SMILES Code: O=C1N(C)C2=C(C=CC3=C2OCO3)C(OC)=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 233.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Wang M, Gao M, Miller KD, Sledge GW, Hutchins GD, Zheng QH. Synthesis of carbon-11-labeled casimiroin analogues as new potential PET agents for imaging of quinone reductase 2 and aromatase expression in breast cancer. Steroids. 2010 Dec;75(12):967-73. doi: 10.1016/j.steroids.2010.06.004. Epub 2010 Jun 15. PMID: 20558190.
2: Maiti A, Reddy PV, Sturdy M, Marler L, Pegan SD, Mesecar AD, Pezzuto JM, Cushman M. Synthesis of casimiroin and optimization of its quinone reductase 2 and aromatase inhibitory activities. J Med Chem. 2009 Apr 9;52(7):1873-84. doi: 10.1021/jm801335z. PMID: 19265439; PMCID: PMC2673050.
3: Froldi G, Bertin R, Secchi E, Zagotto G, Martínez-Vázquez M, García-Argaéz A. Vasorelaxation by extracts of Casimiroa spp. in rat resistance vessels and pharmacological study of cellular mechanisms. J Ethnopharmacol. 2011 Apr 12;134(3):637-43. doi: 10.1016/j.jep.2011.01.008. Epub 2011 Jan 12. PMID: 21236328.
