Calcitonin | CAS# 47931-85-1 | Calcium-Regulating Hormone

Calcitonin
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 412424

CAS#: 47931-85-1

Description: Calcitonin is a 32 amino acid peptide hormone secreted by parafollicular cells of the thyroid gland in humans, and in many other animals in the ultimopharyngeal body. It acts to reduce blood calcium, opposing the effects of parathyroid hormone. Calcitonin has been found in fish, reptiles, birds, and mammals.

Chemical Structure

Calcitonin

CAS# 47931-85-1

Instruction

Theoretical Analysis

MedKoo Cat#: 412424
Name: Calcitonin
CAS#: 47931-85-1
Chemical Formula: C145H240N44O48S2
Exact Mass: 3,429.71
Molecular Weight: 3,431.890
Elemental Analysis: C, 50.75; H, 7.05; N, 17.96; O, 22.38; S, 1.87

Price and Availability

Size	Price	Availability	Quantity
1mg	USD 1400	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: Calcitonin; Astronin; Osteobion; Steocin; TZ-CT

IUPAC/Chemical Name: (4S)-4-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[2-[[(2S)-2-[[(2S)-2-[[(4R,7S,10S,13S,16S,19S,22R)-22-amino-16-(2-amino-2-oxoethyl)-7-[(1R)-1-hydroxyethyl]-10,19-bis(hydroxymethyl)-13-(2-methylpropyl)-6,9,12,15,18,21-hexaoxo-1,2-dithia-5,8,11,14,17,20-hexazacyclotricosane-4-carbonyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]acetyl]amino]hexanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]-5-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S,3R)-1-[[(2S)-1-[(2S)-2-[[(2S)-1-[[(2S,3R)-1-[[(2S)-4-amino-1-[[(2S,3R)-1-[[2-[[(2S)-1-[[2-[[(2S,3R)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-3-hydroxy-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-oxopentanoic acid

InChi Key: BBBFJLBPOGFECG-VJVYQDLKSA-N

InChi Code: InChI=1S/C145H240N44O48S2/c1-65(2)45-86(175-139(232)110(70(11)12)183-136(229)99-63-239-238-62-79(148)117(210)178-96(59-191)134(227)174-92(52-104(151)202)131(224)172-90(49-69(9)10)129(222)180-98(61-193)135(228)187-114(74(16)197)142(235)181-99)118(211)158-55-106(204)162-80(25-18-20-40-146)120(213)169-89(48-68(7)8)128(221)179-97(60-192)133(226)167-83(34-37-102(149)200)122(215)165-85(36-39-109(207)208)123(216)171-88(47-67(5)6)127(220)173-91(51-77-54-156-64-161-77)130(223)164-81(26-19-21-41-147)121(214)170-87(46-66(3)4)126(219)166-84(35-38-103(150)201)125(218)186-113(73(15)196)141(234)177-94(50-76-30-32-78(199)33-31-76)143(236)189-44-24-29-101(189)137(230)168-82(27-22-42-157-145(154)155)124(217)185-112(72(14)195)140(233)176-93(53-105(152)203)132(225)184-111(71(13)194)138(231)160-56-107(205)163-95(58-190)119(212)159-57-108(206)182-115(75(17)198)144(237)188-43-23-28-100(188)116(153)209/h30-33,54,64-75,79-101,110-115,190-199H,18-29,34-53,55-63,146-148H2,1-17H3,(H2,149,200)(H2,150,201)(H2,151,202)(H2,152,203)(H2,153,209)(H,156,161)(H,158,211)(H,159,212)(H,160,231)(H,162,204)(H,163,205)(H,164,223)(H,165,215)(H,166,219)(H,167,226)(H,168,230)(H,169,213)(H,170,214)(H,171,216)(H,172,224)(H,173,220)(H,174,227)(H,175,232)(H,176,233)(H,177,234)(H,178,210)(H,179,221)(H,180,222)(H,181,235)(H,182,206)(H,183,229)(H,184,225)(H,185,217)(H,186,218)(H,187,228)(H,207,208)(H4,154,155,157)/t71-,72-,73-,74-,75-,79+,80+,81+,82+,83+,84+,85+,86+,87+,88+,89+,90+,91+,92+,93+,94+,95+,96+,97+,98+,99+,100+,101+,110+,111+,112+,113+,114+,115+/m1/s1

SMILES Code: CC(C[C@@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N1CCC[C@H]1C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(NCC(N[C@H](C(N2CCC[C@H]2C(N)=O)=O)[C@H](O)C)=O)=O)CO)=O)=O)[C@H](O)C)=O)CC(N)=O)=O)[C@H](O)C)=O)CCCNC(N)=N)=O)=O)Cc3ccc(O)cc3)=O)[C@H](O)C)=O)CCC(N)=O)=O)CC(C)C)=O)CCCCN)=O)Cc4[nH]cnc4)=O)CC(C)C)=O)CCC(O)=O)=O)CCC(N)=O)=O)CO)=O)CC(C)C)=O)CCCCN)=O)=O)NC([C@H](C(C)C)NC([C@@H]5CSSC[C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N5)=O)[C@H](O)C)=O)CO)=O)CC(C)C)=O)CC(N)=O)=O)CO)=O)N)=O)=O)C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 3,431.89 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Srinivasan A, Wong FK, Karponis D. Calcitonin: A useful old friend. J Musculoskelet Neuronal Interact. 2020 Dec 1;20(4):600-609. PMID: 33265089; PMCID: PMC7716677.

2: Sexton PM, Findlay DM, Martin TJ. Calcitonin. Curr Med Chem. 1999 Nov;6(11):1067-93. PMID: 10519914.

3: Potts JT Jr, Niall HD, Deftos LJ. Calcitonin. Curr Top Exp Endocrinol. 1971;1:151-73. doi: 10.1016/b978-0-12-153201-7.50011-9. PMID: 4949942.

4: Anast CS, Conaway HH. Calcitonin. Clin Orthop Relat Res. 1972 May;84:207-62. doi: 10.1097/00003086-197205000-00034. PMID: 4555851.

5: Itabashi A. [Calcitonin]. Nihon Rinsho. 1998 Jun;56(6):1511-7. Japanese. PMID: 9648474.

6: Silverman SL. Nasal calcitonin. Endocrine. 1997 Apr;6(2):199-202. doi: 10.1007/BF02738965. PMID: 9225136.

7: Reginster JY. La calcitonine [Calcitonin]. Rev Med Liege. 1996 Jan;51(1):116-9. French. PMID: 8701121.

8: Neundorf I, Beck-Sickinger AG. Calcitonin-derived carrier peptides. Curr Pharm Des. 2005;11(28):3661-9. doi: 10.2174/138161205774580723. PMID: 16305502.

9: Martin TJ. Calcitonin, an update. Bone. 1999 May;24(5 Suppl):63S-65S. doi: 10.1016/s8756-3282(99)00068-x. PMID: 10321932.

10: Franceschini R, Cataldi A, Cianciosi P, Garibaldi A, Corsini G, Barreca T, Rolandi E. Calcitonin and beta-endorphin secretion. Biomed Pharmacother. 1993;47(8):305-9. doi: 10.1016/0753-3322(93)90079-z. PMID: 8061253.

11: Muñoz-Torres M, Alonso G, Raya MP. Calcitonin therapy in osteoporosis. Treat Endocrinol. 2004;3(2):117-32. doi: 10.2165/00024677-200403020-00006. PMID: 15743107.

12: Maricic MJ. Oral calcitonin. Curr Osteoporos Rep. 2012 Mar;10(1):80-5. doi: 10.1007/s11914-011-0084-x. PMID: 22281725.

13: Calcitonin. Br Med J. 1968 Jul 6;3(5609):3-4. PMID: 5661913; PMCID: PMC1991274.

14: Body JJ. Calcitonin: what is new in 1992? Acta Clin Belg. 1992;47(2):77-81. doi: 10.1080/17843286.1992.11718213. PMID: 1321540.

15: Austin LA, Heath H 3rd. Calcitonin: physiology and pathophysiology. N Engl J Med. 1981 Jan 29;304(5):269-78. doi: 10.1056/NEJM198101293040505. PMID: 7003392.

16: Copp DH. Calcitonin. Adv Intern Med. 1968;14:55-82. PMID: 4883746.

17: Rico Lenza H. La calcitonina hoy [Calcitonin today]. Rev Clin Esp. 2003 Mar;203(3):115-7. Spanish. doi: 10.1157/13044919. PMID: 12646078.

18: Kanis JA. Calcitonin in osteoporosis. Bone. 2002 May;30(5 Suppl):65S-66S. doi: 10.1016/s8756-3282(02)00712-3. PMID: 12008160.

19: Vik A, Yatham LN. Calcitonin and bipolar disorder: a hypothesis revisited. J Psychiatry Neurosci. 1998 Mar;23(2):109-17. PMID: 9549251; PMCID: PMC1188909.

20: Kraiem A, el May M, Guermazi F, Mtimet S. La calcitonine [Calcitonin]. Tunis Med. 1989 Aug-Sep;67(8-9):473-9. French. PMID: 2678643.

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