Lanicemine dihydrochloride

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 575019

CAS#: 153322-06-6

Description: Lanicemine dihydrochloride is a low-trapping NMDA receptor antagonist. Lanicemine is used in the management of severe treatment-resistant depression.

Chemical Structure

Lanicemine dihydrochloride
CAS# 153322-06-6

Theoretical Analysis

MedKoo Cat#: 575019
Name: Lanicemine dihydrochloride
CAS#: 153322-06-6
Chemical Formula: C13H16Cl2N2
Exact Mass: 270.0691
Molecular Weight: 271.18
Elemental Analysis: C, 57.58; H, 5.95; Cl, 26.14; N, 10.33

Price and Availability

Size Price Availability Quantity
5.0mg USD 245.0 2 Weeks
25.0mg USD 690.0 2 Weeks
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Synonym: ARL-15896AR; AZD-6765 dihydrochloride; FPL-15896AR; Lanicemine dihydrochloride; Lanicemine 2HCl

IUPAC/Chemical Name: 2-Pyridineethanamine, alpha-phenyl-, (alphaS)-, dihydrochloride


InChi Code: InChI=1S/C13H14N2.2ClH/c14-13(11-6-2-1-3-7-11)10-12-8-4-5-9-15-12;;/h1-9,13H,10,14H2;2*1H/t13-;;/m0../s1

SMILES Code: Cl.Cl.N[C@@H](Cc1ccccn1)c2ccccc2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 271.18 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Wallach J, Kang H, Colestock T, Morris H, Bortolotto ZA, Collingridge GL, Lodge D, Halberstadt AL, Brandt SD, Adejare A. Pharmacological Investigations of the Dissociative 'Legal Highs' Diphenidine, Methoxphenidine and Analogues. PLoS One. 2016 Jun 17;11(6):e0157021. doi: 10.1371/journal.pone.0157021. eCollection 2016. PubMed PMID: 27314670; PubMed Central PMCID: PMC4912077.

2: Downey D, Dutta A, McKie S, Dawson GR, Dourish CT, Craig K, Smith MA, McCarthy DJ, Harmer CJ, Goodwin GM, Williams S, Deakin JF. Comparing the actions of lanicemine and ketamine in depression: key role of the anterior cingulate. Eur Neuropsychopharmacol. 2016 Jun;26(6):994-1003. doi: 10.1016/j.euroneuro.2016.03.006. Epub 2016 Apr 28. PubMed PMID: 27133029.

3: Keavy D, Bristow LJ, Sivarao DV, Batchelder M, King D, Thangathirupathy S, Macor JE, Weed MR. The qEEG Signature of Selective NMDA NR2B Negative Allosteric Modulators; A Potential Translational Biomarker for Drug Development. PLoS One. 2016 Apr 1;11(4):e0152729. doi: 10.1371/journal.pone.0152729. eCollection 2016. PubMed PMID: 27035340; PubMed Central PMCID: PMC4817977.