FAPL-PI3Ki1

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 463359

CAS#: unknown

Description: FAPL-PI3Ki1 is a novel FAP-targeted PI3K inhibitor, suppressing phosphorylation of Akt in IPF fibroblasts.

Chemical Structure

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FAPL-PI3Ki1
CAS# unknown
Instruction

Theoretical Analysis

MedKoo Cat#: 463359
Name: FAPL-PI3Ki1
CAS#: unknown
Chemical Formula: C52H48F4N10O12S3
Exact Mass: 1,176.26
Molecular Weight: 1,177.188
Elemental Analysis: C, 53.06; H, 4.11; F, 6.46; N, 11.90; O, 16.31; S, 8.17

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: FAPL-PI3Ki1; FAPL PI3Ki1; FAP-targeted PI3Ki; FAP targeted PI3Ki;

IUPAC/Chemical Name: N-(4-(((4-(((S)-1-((S)-2-cyano-4,4-difluoropyrrolidin-1-yl)-1-oxopropan-2-yl)carbamoyl)pyridin-2-yl)methyl)amino)-4-oxobutanoyl)-S-((2-((((5-(6-(5-((2,4-difluorophenyl)sulfonamido)-6-methoxypyridin-3-yl)quinolin-4-yl)pyridin-2-yl)methoxy)carbonyl)oxy)ethyl)thio)-L-cysteine

InChi Key: DXXIUVWNTLDCDL-QWSSMIDASA-N

InChi Code: InChI=1S/C52H48F4N10O12S3/c1-29(49(70)66-28-52(55,56)21-37(66)22-57)63-47(69)31-11-13-58-36(17-31)25-61-45(67)9-10-46(68)64-43(50(71)72)27-80-79-16-15-77-51(73)78-26-35-6-3-32(23-60-35)38-12-14-59-41-7-4-30(18-39(38)41)33-19-42(48(76-2)62-24-33)65-81(74,75)44-8-5-34(53)20-40(44)54/h3-8,11-14,17-20,23-24,29,37,43,65H,9-10,15-16,21,25-28H2,1-2H3,(H,61,67)(H,63,69)(H,64,68)(H,71,72)/t29-,37-,43-/m0/s1

SMILES Code: O=C(O)[C@H](CSSCCOC(OCC1=NC=C(C2=CC=NC3=CC=C(C4=CC(NS(=O)(C5=CC=C(F)C=C5F)=O)=C(OC)N=C4)C=C23)C=C1)=O)NC(CCC(NCC6=NC=CC(C(N[C@@H](C)C(N7[C@H](C#N)CC(F)(F)C7)=O)=O)=C6)=O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 1,177.19 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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