Cartazolate

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 412406

CAS#: 34966-41-1

Description: Cartazolate is an Antidepressant


Chemical Structure

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Cartazolate
CAS# 34966-41-1

Theoretical Analysis

MedKoo Cat#: 412406
Name: Cartazolate
CAS#: 34966-41-1
Chemical Formula: C15H22N4O2
Exact Mass: 290.1743
Molecular Weight: 290.37
Elemental Analysis: C, 62.05; H, 7.64; N, 19.30; O, 11.02

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Cartazolate, NSC166873, NSC-166873,NSC 166873

IUPAC/Chemical Name: 1H-Pyrazolo(3,4-b)pyridine-5-carboxylic acid, 4-(butylamino)-1-ethyl-, ethyl ester

InChi Key: IQNQAOGGWGCROX-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H22N4O2/c1-4-7-8-16-13-11-10-18-19(5-2)14(11)17-9-12(13)15(20)21-6-3/h9-10H,4-8H2,1-3H3,(H,16,17)

SMILES Code: O=C(C1=CN=C(N(CC)N=C2)C2=C1NCCCC)OCC

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 290.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Kripalani KJ, Dreyfuss J, Nemec J, Cohen AI, Meeker F, Egli P. Biotransformation in the monkey of cartazolate (SQ 65,396), a substituted pyrazolopyridine having anxiolytic activity. Xenobiotica. 1981 Jul;11(7):481-8. doi: 10.3109/00498258109045858. PMID: 6117154.

2: Sathananthan G, Mir P, Minn FL, Gershon S. Antidepressant predictability: cartazolate. Curr Ther Res Clin Exp. 1976 Apr;19(4):475-8. PMID: 816605.

3: Psychoyos S, Ford CJ, Phillips MA. Inhibition by etazolate (SQ 20009) and cartazolate (SQ 65396) of adenosine-stimulated [3H]cAMP formation in [2-3H]adenine-prelabeled vesicles prepared from guinea pig cerebral cortex. Biochem Pharmacol. 1982 Apr 1;31(7):1441-2. doi: 10.1016/0006-2952(82)90041-7. PMID: 6284176.

4: Hammond JR, Martin IL. Modulation of [3H]flunitrazepam binding to rat cerebellar benzodiazepine receptors by phosphatidylserine. Eur J Pharmacol. 1987 May 7;137(1):49-58. doi: 10.1016/0014-2999(87)90181-6. PMID: 3038577.

5: Supavilai P, Karobath M. Action of pyrazolopyridines as modulators of [3H]flunitrazepam binding to the gaba/benzodiazepine receptor complex of the cerebellum. Eur J Pharmacol. 1981 Mar 12;70(2):183-93. doi: 10.1016/0014-2999(81)90213-2. PMID: 6114867.

6: Hammond JR, Martin IL. Solubilization of the benzodiazepine/gamma- aminobutyric acid receptor complex: comparison of the detergents octylglucopyranoside and 3-[(3-cholamidopropyl)-dimethylammonio]1-propanesulfonate (CHAPS). J Neurochem. 1986 Oct;47(4):1161-71. doi: 10.1111/j.1471-4159.1986.tb00735.x. PMID: 3018163.

7: Koenig JA, Martin IL. Effect of free fatty acids on GABAA receptor ligand binding. Biochem Pharmacol. 1992 Jul 7;44(1):11-5. doi: 10.1016/0006-2952(92)90031-d. PMID: 1321625.

8: Niehoff DL, Mashal RD, Horst WD, O'Brien RA, Palacios JM, Kuhar MJ. Binding of a radiolabeled triazolopyridazine to a subtype of benzodiazepine receptor in the rat cerebellum. J Pharmacol Exp Ther. 1982 Jun;221(3):670-5. PMID: 6283058.

9: Wachtel H. Characteristic behavioural alterations in rats induced by rolipram and other selective adenosine cyclic 3', 5'-monophosphate phosphodiesterase inhibitors. Psychopharmacology (Berl). 1982;77(4):309-16. doi: 10.1007/BF00432761. PMID: 6182575.

10: Williams M. Anxioselective anxiolytics. J Med Chem. 1983 May;26(5):619-28. doi: 10.1021/jm00359a001. PMID: 6132997.