WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 412401
CAS#: 132199-13-4 (salt)
Description: Carsatrin succinate is the salt form on Carsatin, a purinylpiperazine derivative patented by Ortho Pharmaceutical Corp. as cardiotonic and antiarrhythmic. Carsatrin acts as positive inotropic agent that increases twitch tension and prolongs the action potential (AP) duration of ventricular muscle without affecting the Na+,K+-ATPase, adenylyl cyclase, phosphodiesterase isozymes, or cardiac myofilaments. Carsatrin’s positive inotropic effect can be prevented by tetrodotoxin but not by the adrenergic antagonists timolol, yohimbine, or prazosin
MedKoo Cat#: 412401
Name: Carsatrin succinate
CAS#: 132199-13-4 (salt)
Chemical Formula: C29H32F2N6O5S
Molecular Weight: 614.67
Elemental Analysis: C, 56.67; H, 5.25; F, 6.18; N, 13.67; O, 13.01; S, 5.22
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Related CAS #: 412400 (free base) 132199-13-4 (salt)
Synonym: Carsatrin succinate; RWJ24517; RWJ-24517; RWJ 24517
IUPAC/Chemical Name: 1-Piperazineethanol, 4-(bis(4-fluorophenyl)methyl)-alpha-((9H-purin-6-ylthio)methyl)-, (+-)-, butanedioate (1:1) (salt)
InChi Key: HITUQCDKZKCYIZ-UHFFFAOYSA-N
InChi Code: InChI=1S/C25H26F2N6OS.C4H6O4/c26-19-5-1-17(2-6-19)23(18-3-7-20(27)8-4-18)33-11-9-32(10-12-33)13-21(34)14-35-25-22-24(29-15-28-22)30-16-31-25;5-3(6)1-2-4(7)8/h1-8,15-16,21,23,34H,9-14H2,(H,28,29,30,31);1-2H2,(H,5,6)(H,7,8)
SMILES Code: OC(CSC1=C2N=CNC2=NC=N1)CN3CCN(C(C4=CC=C(F)C=C4)C5=CC=C(F)C=C5)CC3.O=C(O)CCC(O)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 614.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Press JB, Falotico R, Hajos ZG, Sawyers RA, Kanojia RM, Williams L, Haertlein B, Kauffman JA, Lakas-Weiss C, Salata JJ. Synthesis and SAR of 6-substituted purine derivatives as novel selective positive inotropes. J Med Chem. 1992 Nov 27;35(24):4509-15. doi: 10.1021/jm00102a001. PMID: 1335073.
2: Tsushima RG, Kelly JE, Salata JJ, Liberty KN, Wasserstrom JA. Modification of cardiac Na(+) current by RWJ 24517 and its enantiomers in guinea pig ventricular myocytes. J Pharmacol Exp Ther. 1999 Nov;291(2):845-55. PMID: 10525108.
3: Krafte DS, Davison K, Dugrenier N, Estep K, Josef K, Barchi RL, Kallen RG, Silver PJ, Ezrin AM. Pharmacological modulation of human cardiac Na+ channels. Eur J Pharmacol. 1994 Feb 15;266(3):245-54. doi: 10.1016/0922-4106(94)90133-3. PMID: 8174607.
4: Kawamura A, Wahler GM, Solaro RJ. RWJ-24517, a positive inotropic agent, has novel effects on action potentials in guinea pig myocardium. J Cardiovasc Pharmacol. 1993 Oct;22(4):519-25. doi: 10.1097/00005344-199310000-00003. PMID: 7505352.