Carpropamid
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 412396

CAS#: 104030-54-8

Description: Carpropamid is a rice fungicide without EU regulatory approval for use.


Chemical Structure

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Carpropamid
CAS# 104030-54-8

Theoretical Analysis

MedKoo Cat#: 412396
Name: Carpropamid
CAS#: 104030-54-8
Chemical Formula: C15H18Cl3NO
Exact Mass: 333.0454
Molecular Weight: 334.67
Elemental Analysis: C, 53.83; H, 5.42; Cl, 31.78; N, 4.19; O, 4.78

Price and Availability

Size Price Availability Quantity
100.0mg USD 207.2 2 Weeks
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Synonym: Carpropamid; UNII-ZS46TAN742

IUPAC/Chemical Name: Cyclopropanecarboxamide, 2,2-dichloro-N-(1-(4-chlorophenyl)ethyl)-1-ethyl-3-methyl-

InChi Key: RXDMAYSSBPYBFW-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H18Cl3NO/c1-4-14(10(3)15(14,17)18)13(20)19-9(2)11-5-7-12(16)8-6-11/h5-10H,4H2,1-3H3,(H,19,20)

SMILES Code: O=C(C1(CC)C(Cl)(Cl)C1C)NC(C2=CC=C(Cl)C=C2)C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 334.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Rohilla R, Singh US, Singh RL. Uptake and translocation of carpropamid in rice (Oryza sativa L). Pest Manag Sci. 2001 Mar;57(3):239-47. doi: 10.1002/ps.255. PMID: 11455653.

2: Takagaki M, Kaku K, Watanabe S, Kawai K, Shimizu T, Sawada H, Kumakura K, Nagayama K. Mechanism of resistance to carpropamid in Magnaporthe grisea. Pest Manag Sci. 2004 Sep;60(9):921-6. doi: 10.1002/ps.896. PMID: 15382507.

3: Nakasako M, Motoyama T, Kurahashi Y, Yamaguchi I. Cryogenic X-ray crystal structure analysis for the complex of scytalone dehydratase of a rice blast fungus and its tight-binding inhibitor, carpropamid: the structural basis of tight-binding inhibition. Biochemistry. 1998 Jul 14;37(28):9931-9. doi: 10.1021/bi980321b. PMID: 9665698.

4: Yamada N, Motoyama T, Nakasako M, Kagabu S, Kudo T, Yamaguchi I. Enzymatic characterization of scytalone dehydratase Val75Met variant found in melanin biosynthesis dehydratase inhibitor (MBI-D) resistant strains of the rice blast fungus. Biosci Biotechnol Biochem. 2004 Mar;68(3):615-21. doi: 10.1271/bbb.68.615. PMID: 15056895.

5: Yu Q, Cao ZY, Dong JG. [Cloning and functional analysis of scytalone dehytratase gene in Exserohilum turcicum]. Wei Sheng Wu Xue Bao. 2007 Dec;47(6):1013-8. Chinese. PMID: 18271256.

6: Yasukochi H, Atago T, Tanaka A, Nakatsuji H, Yoshida E, Kakehi A, Nishii Y, Tanabe Y. Practical, general, and systematic method for optical resolution of gem-dihalo- and monohalocyclopropanecarboxylic acids utilizing chiral 1,1'-binaphtholmonomethyl ethers: application to the synthesis of three chiral pesticides. Org Biomol Chem. 2008 Feb 7;6(3):540-7. doi: 10.1039/b714614k. Epub 2007 Dec 18. PMID: 18219425.

7: Sawada H, Sugihara M, Takagaki M, Nagayama K. Monitoring and characterization of Magnaporthe grisea isolates with decreased sensitivity to scytalone dehydratase inhibitors. Pest Manag Sci. 2004 Aug;60(8):777-85. doi: 10.1002/ps.858. PMID: 15307669.

8: Kaku K, Takagaki M, Shimizu T, Nagayama K. Diagnosis of dehydratase inhibitors in melanin biosynthesis inhibitor (MBI-D) resistance by primer- introduced restriction enzyme analysis in scytalone dehydratase gene of Magnaporthe grisea. Pest Manag Sci. 2003 Aug;59(8):843-6. doi: 10.1002/ps.742. PMID: 12916764.