WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 412387
CAS#: 5942-95-0 (free base)
Description: Carpipramine (free base) is an atypical antipsychotic used for the treatment of schizophrenia and anxiety in France and Japan. In addition to its neuroleptic and anxiolytic effects, carpipramine also has hypnotic properties. It is structurally related to both tricyclics like imipramine and butyrophenones like haloperidol.
MedKoo Cat#: 412387
Name: Carpipramine (free base)
CAS#: 5942-95-0 (free base)
Chemical Formula: C28H38N4O
Exact Mass: 446.3046
Molecular Weight: 446.64
Elemental Analysis: C, 75.30; H, 8.58; N, 12.54; O, 3.58
This product is not in stock, which may be available by custom synthesis.
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Related CAS #: 5942-95-0 (free base) 7075-03-8 (HCl)
Synonym: Carpipramine (free base); PZ1511; PZ-1511; PZ 1511
IUPAC/Chemical Name: 1'-(3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)propyl)-[1,4'-bipiperidine]-4'-carboxamide
InChi Key: NWPJLRSCSQHPJV-UHFFFAOYSA-N
InChi Code: InChI=1S/C28H38N4O/c29-27(33)28(31-18-6-1-7-19-31)15-21-30(22-16-28)17-8-20-32-25-11-4-2-9-23(25)13-14-24-10-3-5-12-26(24)32/h2-5,9-12H,1,6-8,13-22H2,(H2,29,33)
SMILES Code: NC(C1(N2CCCCC2)CCN(CC1)CCCN3c4c(CCc5c3cccc5)cccc4)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 446.64 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: des Lauriers A, Clery-Melin P, Allilaire JF, Baruch P, Ammar S, Vilamot B. A propos de la carpipramine [Carpipramine]. Encephale. 1990 Jan-Feb;16(1):53. French. PMID: 2328685.
2: Kishi T, Matsunaga S, Matsuda Y, Iwata N. Iminodibenzyl class antipsychotics for schizophrenia: a systematic review and meta-analysis of carpipramine, clocapramine, and mosapramine. Neuropsychiatr Dis Treat. 2014 Dec 10;10:2339-51. doi: 10.2147/NDT.S73464. PMID: 25525363; PMCID: PMC4266422.
3: Woggon B, Angst J. Das Wirkungsprofil von Carpipramin. Ergebnisse einer offenen Prüfung und einer Doppelblindprüfung gegen Doxepin [Activity profile of carpipramine. Results of an open trial and a double-blind trial versus doxepin]. Arzneimittelforschung. 1976;26(12):2226-30. German. PMID: 14652.
4: Sechter D, Loo H. Les antagonistes 5HT2* et la carpipramine [5 HT2 antagonists and carpipramine]. Rev Prat. 1990 Nov 1;40(25):2363-5. French. PMID: 2124722.
5: Deniker P, Lôo H, Zarifian E, Verdeaux G, Garreau G. Un nouveau médicament psychotrope: la carpipramine, composé de transition entre deux classes thérapeutiques [A new psychotropic drug: carpipramine, intermediate compound between 2 therapeutic classes]. Encephale. 1977;3(2):133-48. French. PMID: 19231.
6: Fontan M, Goudemand M, Roeland P, Gamblin P. La carpipramine comme traitement de l'inhibition [Carpipramine as treatment of inhibition]. Lille Med. 1979 Feb;24(2):151-5. French. PMID: 372716.
7: Peyrouzet JM, Périer M. La carpipramine dans les névroses [Carpipramine in neuroses]. Encephale. 1978;4(5 Suppl):577-85. French. PMID: 380971.
8: Athen D, Bente D, Bikadorow V, Feder J, Müller-Oerlinghausen B. Das klinische Wirkungsspektrum mittlerer und hoher Dosen von Carpipramin [Clinical effects of moderate and high doses of carpipramine (author's transl)]. Pharmakopsychiatr Neuropsychopharmakol. 1975 Sep;8(5):269-309. German. PMID: 1233521.
9: Dagonneau H, Fonlupt P, Pacheco H. Effets, chez le Rat, de la métapramine et de la carpipramine sur le recaptage des catécholamines et de la sérotonine; relation avec la fixation de l'3H-imipramine [Effects, in rats, of metapramine and carpipramine on the uptake of catecholamines and serotonin; relationship with 3H-imipramine binding]. C R Seances Soc Biol Fil. 1986;180(1):43-8. French. PMID: 3017518.
10: von Stralendorff B, Ackenheil M, Zimmermann J. Akute und chronische Wirkung von Carpipramin, Clozapin, Haloperidol und Sulpirid auf den Stoffwechsel biogener Amine im Rattengehirn [Acute and chronic effects of carpipramine, clozapine, haloperidol and sulpiride on the metabolism of biogenic amines in the rat brain (author's transl)]. Arzneimittelforschung. 1976;26(6):1096-8. German. PMID: 9108.
