WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 412383
CAS#: 66203-00-7
Description: Carocainide is an antiarrhythmic drug
MedKoo Cat#: 412383
Name: Carocainide
CAS#: 66203-00-7
Chemical Formula: C18H25N3O5
Exact Mass: 363.1794
Molecular Weight: 363.41
Elemental Analysis: C, 59.49; H, 6.93; N, 11.56; O, 22.01
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Synonym: Carocainide; BRN5154193; BRN-5154193; BRN 5154193; Carocainidum
IUPAC/Chemical Name: 1-(4,7-Dimethoxy-6-(2-(1-pyrrolidinyl)ethoxy)-5-benzofuranyl)-3-methylurea
InChi Key: BWMMRMDCODVQBX-UHFFFAOYSA-N
InChi Code: InChI=1S/C18H25N3O5/c1-19-18(22)20-13-14(23-2)12-6-10-25-15(12)17(24-3)16(13)26-11-9-21-7-4-5-8-21/h6,10H,4-5,7-9,11H2,1-3H3,(H2,19,20,22)
SMILES Code: O=C(NC)NC1=C(OCCN2CCCC2)C(OC)=C(OC=C3)C3=C1OC
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 363.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Rovei V, Strolin Benedetti M, Daniel C, Moulin A, Donath A. Pharmacokinetics and metabolism of the anti-arrhythmic carocainide in man. Xenobiotica. 1985 Nov;15(11):953-64. doi: 10.3109/00498258509045048. PMID: 4082635.
2: Muramoto J, Hotokebuchi N, Nishi K. Effect of an antiarrhythmic agent, carocainide, on action potentials of ventricular papillary muscle of the guinea- pig heart in vitro. Arch Int Pharmacodyn Ther. 1991 Jul-Aug;312:27-38. PMID: 1772338.
3: Bach P, Steinbeck G. Electrophysiologic and antiarrhythmic effects of carocainide in humans. J Cardiovasc Pharmacol. 1988 Dec;12(6):637-42. doi: 10.1097/00005344-198812000-00003. PMID: 2467080.
4: Zannad F, Aliot E, Baille N, Gilgenkrantz JM. Effets électrophysiologiques du carocaïnide intraveineux [Electrophysiologic effects of intravenous carocainide]. Arch Mal Coeur Vaiss. 1986 Feb;79(2):236-41. French. PMID: 3085623.
5: Huerta F, Pourrias B. Effects of carocainide (770207) on canine cardiac automaticity. Arch Int Pharmacodyn Ther. 1984 Apr;268(2):216-24. PMID: 6732365.
6: Pourrias B, Huerta F, Santamaria R, Tisne Versailles J. Effects of MD770207 (carocainide) on experimental ventricular arrhythmias. Arch Int Pharmacodyn Ther. 1983 May;263(1):85-102. PMID: 6615084.
7: Pourrias B, Santamaria R. Electrophysiological effects of carocainide (770207) on canine ventricular muscle and Purkinje fibers. Arch Int Pharmacodyn Ther. 1983 Sep;265(1):85-95. PMID: 6316863.
8: Huerta F, Santamaria R, Pourrias B. Electrophysiological effects of carocainide (770207) on the dog heart. Arch Int Pharmacodyn Ther. 1984 Feb;267(2):289-98. PMID: 6712362.
