Carnitine orotate | CAS# 32543-38-7

Carnitine orotate
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 412379

CAS#: 32543-38-7

Description: Carnitine orotate is a biochemical

Chemical Structure

Carnitine orotate

CAS# 32543-38-7

Instruction

Theoretical Analysis

MedKoo Cat#: 412379
Name: Carnitine orotate
CAS#: 32543-38-7
Chemical Formula: C12H19N3O7
Exact Mass: 317.12
Molecular Weight: 317.290
Elemental Analysis: C, 45.42; H, 6.04; N, 13.24; O, 35.30

Price and Availability

Size	Price	Availability
1g	USD 300	2 Weeks
10g	USD 455	2 Weeks
100g	USD 725	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: Carnitine orotate; UNII83EYV27FW2; UNII 83EYV27FW2; UNII-83EYV27FW2

IUPAC/Chemical Name: 1-Propanaminium, 3-carboxy-2-hydroxy-N,N,N-trimethyl-, 1,2,3,6-tetrahydro-2,6-dioxo-4-pyrimidinecarboxylate (1:1)

InChi Key: MBULCFMSBDQQQT-UHFFFAOYSA-N

InChi Code: InChI=1S/C7H15NO3.C5H4N2O4/c1-8(2,3)5-6(9)4-7(10)11;8-3-1-2(4(9)10)6-5(11)7-3/h6,9H,4-5H2,1-3H3;1H,(H,9,10)(H2,6,7,8,11)

SMILES Code: C[N+](C)(C)CC(O)CC(O)=O.O=C(C(NC1=O)=CC(N1)=O)[O-]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 317.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Zhu HS, Wang YY, Lin MW, Du JX, Hang LQ, Chen Y, Wang LF. Carnitine and carnitine orotate affect the expression of the prolactin-releasing peptide gene. Genet Mol Res. 2011 Dec 6;10(4):3013-9. doi: 10.4238/2011.December.6.1. PMID: 22180034.

2: An JH, Youn W, Kiyonga AN, Lim C, Park M, Suh YG, Ryu HC, Kim JS, Park CW, Jung K. Kinetics of the Solution-Mediated Polymorphic Transformation of the Novel l-Carnitine Orotate Polymorph, Form-II. Pharmaceutics. 2018 Oct 1;10(4):171. doi: 10.3390/pharmaceutics10040171. PMID: 30275413; PMCID: PMC6321437.

3: Bae JC, Lee WY, Yoon KH, Park JY, Son HS, Han KA, Lee KW, Woo JT, Ju YC, Lee WJ, Cho YY, Lee MK. Improvement of Nonalcoholic Fatty Liver Disease With Carnitine-Orotate Complex in Type 2 Diabetes (CORONA): A Randomized Controlled Trial. Diabetes Care. 2015 Jul;38(7):1245-52. doi: 10.2337/dc14-2852. Epub 2015 Apr 15. PMID: 25877813.

4: Hong ES, Kim EK, Kang SM, Khang AR, Choi SH, Park KS, Jang HC, Lim S. Effect of carnitine-orotate complex on glucose metabolism and fatty liver: a double- blind, placebo-controlled study. J Gastroenterol Hepatol. 2014;29(7):1449-57. doi: 10.1111/jgh.12536. PMID: 24611967.

5: Nunes V, Niinikoski H. Lysinuric Protein Intolerance. 2006 Dec 21 [updated 2018 Apr 12]. In: Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens K, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2020. PMID: 20301535.

6: Chen Q, Liu M, Yu H, Li J, Wang S, Zhang Y, Qiu F, Wang T. Scutellaria baicalensis regulates FFA metabolism to ameliorate NAFLD through the AMPK- mediated SREBP signaling pathway. J Nat Med. 2018 Jun;72(3):655-666. doi: 10.1007/s11418-018-1199-5. Epub 2018 Mar 14. PMID: 29542003.

7: Guan HZ, Ding Y, Li DX, Dong H, Song JQ, Jin Y, Zhu ZJ, Sun LY, Yang YL. [Clinical diagnosis and treatment of three cases with hyperornithinemia- hyperammonemia-homocitrullinuria syndrome]. Zhonghua Er Ke Za Zhi. 2017 Jun 2;55(6):428-433. Chinese. doi: 10.3760/cma.j.issn.0578-1310.2017.06.007. PMID: 28592010.

8: Sundekilde UK, Gustavsson F, Poulsen NA, Glantz M, Paulsson M, Larsen LB, Bertram HC. Association between the bovine milk metabolome and rennet-induced coagulation properties of milk. J Dairy Sci. 2014 Oct;97(10):6076-84. doi: 10.3168/jds.2014-8304. Epub 2014 Jul 30. PMID: 25087032.

9: Held PK, Haynes CA, De Jesús VR, Baker MW. Development of an assay to simultaneously measure orotic acid, amino acids, and acylcarnitines in dried blood spots. Clin Chim Acta. 2014 Sep 25;436:149-54. doi: 10.1016/j.cca.2014.05.016. Epub 2014 Jun 2. PMID: 24886687; PMCID: PMC4835024.

10: Lu J, Boeren S, van Hooijdonk T, Vervoort J, Hettinga K. Effect of the DGAT1 K232A genotype of dairy cows on the milk metabolome and proteome. J Dairy Sci. 2015 May;98(5):3460-9. doi: 10.3168/jds.2014-8872. Epub 2015 Mar 12. PMID: 25771043.

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