Carminomicin III

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 412361

CAS#: 50935-06-3 (III)

Description: Carminomicin III is a very toxic anthracycline-type antineoplastic related to DAUNORUBICIN, obtained from Actinomadura carminata.

Chemical Structure

img
Carminomicin III
CAS# 50935-06-3 (III)
Instruction

Theoretical Analysis

MedKoo Cat#: 412361
Name: Carminomicin III
CAS#: 50935-06-3 (III)
Chemical Formula: C33H41NO13
Exact Mass: 659.26
Molecular Weight: 659.690
Elemental Analysis: C, 60.08; H, 6.26; N, 2.12; O, 31.53

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Related CAS #: 50935-05-2 (II)   50935-06-3 (III)  

Synonym: Carminomicin III, Carminomicin 3

IUPAC/Chemical Name: 8-acetyl-10-((4-amino-5-(3-hydroxy-1-((1-hydroxypropan-2-yl)oxy)butoxy)-6-methyltetrahydro-2H-pyran-2-yl)oxy)-1,6,8,11-tetrahydroxy-7,8,9,10-tetrahydrotetracene-5,12-dione

InChi Key: DNHXZQIEIKSDIK-UHFFFAOYSA-N

InChi Code: InChI=1S/C33H41NO13/c1-13(36)8-22(44-14(2)12-35)47-32-15(3)45-23(9-19(32)34)46-21-11-33(43,16(4)37)10-18-25(21)31(42)27-26(29(18)40)28(39)17-6-5-7-20(38)24(17)30(27)41/h5-7,13-15,19,21-23,32,35-36,38,40,42-43H,8-12,34H2,1-4H3

SMILES Code: O=C1C2=C(O)C(CC(O)(C(C)=O)CC3OC4CC(N)C(OC(OC(C)CO)CC(O)C)C(C)O4)=C3C(O)=C2C(C5=C1C=CC=C5O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 659.69 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Gause GF. Antitumor antibiotic carminomycin. Z Allg Mikrobiol. 1980;20(3):219-25. PMID: 6158803.

2: Woldemichael GM, Turbyville TJ, Linehan WM, McMahon JB. Carminomycin I is an apoptosis inducer that targets the Golgi complex in clear cell renal carcinoma cells. Cancer Res. 2011 Jan 1;71(1):134-42. doi: 10.1158/0008-5472.CAN-10-0757. PMID: 21199801; PMCID: PMC3074515.

3: Tevyashova AN, Shtil AA, Olsufyeva EN, Simonova VS, Samusenko AV, Preobrazhenskaya MN. Carminomycin, 14-hydroxycarminomycin and its novel carbohydrate derivatives potently kill human tumor cells and their multidrug resistant variants. J Antibiot (Tokyo). 2004 Feb;57(2):143-50. doi: 10.7164/antibiotics.57.143. PMID: 15112963.

4: Rozencweig M, ten Bokkel Huinink W, Cavalli F, Bruntsch U, Dombernowsky P, Høst H, Bramwell V, Renard G, Van Glabbeke M, Decoster G. Randomized phase II trial of carminomycin versus 4'-epidoxorubicin in advanced breast cancer. J Clin Oncol. 1984 Apr;2(4):275-81. doi: 10.1200/JCO.1984.2.4.275. PMID: 6584561.

5: Kochetkova GV, Gladkikh EG, Ponomarenko VI. Vliianie pH sredy na rost produtsenta karminomitsina i biosintez karminomitsinovogo kompleksa [Effect of the pH of the medium on the growth of a carminomycin producer and on the biosynthesis of the carminomycin complex]. Antibiotiki. 1977 May;22(5):387-91. Russian. PMID: 879720.

6: Crooke ST. A review of carminomycin-a new anthracycline developed in the USSR. J Med. 1977;8(5):295-316. PMID: 338849.

7: Liashenko VA, Shapovalova SP, Aleksander SK, Povarov LS. Protivovirusnoe deĭstvie karminomitsina i nekotorykh ego proizvodnykh [Antiviral action of carminomycin and some of its derivatives]. Antibiotiki. 1978 Nov;23(11):1009-15. Russian. PMID: 214027.

8: Aleksander SK, Liashenko VA, Iakushkina IV. Sravnenie protivoopukholevykh, immunodepressivnykh i toksicheskikh svoĭstv kompleksov karminomitsina s al'buminom razlichaiushchikhsia po soderzhaniiu karminomitsina [Comparison of the antitumor, immunodepressive and toxic properties of carminomycin-albumin complexes differing in carminomycin content]. Antibiotiki. 1981 Apr;26(4):298-302. Russian. PMID: 6894522.

9: Muggia FM, Green MD. New anthracycline antitumor antibiotics. Crit Rev Oncol Hematol. 1991;11(1):43-64. doi: 10.1016/1040-8428(91)90017-7. PMID: 1831987.

10: Young RC, Ozols RF, Myers CE. The anthracycline antineoplastic drugs. N Engl J Med. 1981 Jul 16;305(3):139-53. doi: 10.1056/NEJM198107163050305. PMID: 7017406.