Carfenazine free base | CAS# 2622-30-2 (free base) | antipsychotic and tranquilizer

Carfenazine free base
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 412352

CAS#: 2622-30-2 (free base)

Description: Carfenazine, also known as WY-2445, or carphenazine (BAN), also known as carphenazine maleate (USAN) (brand name Proketazine; former developmental code name NSC-71755), is an antipsychotic and tranquilizer of the phenothiazine group that was withdrawn from the market. Carphenazine blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; depresses the release of hypothalamic and hypophyseal hormones and is believed to depress the reticular activating system thus affecting basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis.

Chemical Structure

Carfenazine free base

CAS# 2622-30-2 (free base)

Instruction

Theoretical Analysis

MedKoo Cat#: 412352
Name: Carfenazine free base
CAS#: 2622-30-2 (free base)
Chemical Formula: C24H31N3O2S
Exact Mass: 425.21
Molecular Weight: 425.590
Elemental Analysis: C, 67.73; H, 7.34; N, 9.87; O, 7.52; S, 7.53

Price and Availability

Size	Price	Availability
5mg	USD 420	2 Weeks
10mg	USD 760	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: NSC-71755; NSC71755; NSC 71755, Carphenazine free base; Proketazine; Proketazine; Procethazine; carphenazine; NSC 71755; WY2445; WY-2445; WY 2445;

IUPAC/Chemical Name: 1-(10-(3-(4-(2-hydroxyethyl)piperazin-1-yl)propyl)-10H-phenothiazin-2-yl)propan-1-one

InChi Key: XZSMZRXAEFNJCU-UHFFFAOYSA-N

InChi Code: InChI=1S/C24H31N3O2S/c1-2-22(29)19-8-9-24-21(18-19)27(20-6-3-4-7-23(20)30-24)11-5-10-25-12-14-26(15-13-25)16-17-28/h3-4,6-9,18,28H,2,5,10-17H2,1H3

SMILES Code: CCC(C(C=C1N2CCCN3CCN(CCO)CC3)=CC=C1SC4=C2C=CC=C4)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 425.59 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: STRATAS NE. CARPHENAZINE IN CHRONIC SCHIZOPHRENICS. Am J Psychiatry. 1964 Mar;120:902-3. doi: 10.1176/ajp.120.9.902. PMID: 14129292.

2: LASALLE MW. CARPHENAZINE IN CHRONIC SCHIZOPHRENIA. Am J Psychiatry. 1964 Nov;121:494-5. doi: 10.1176/ajp.121.5.494. PMID: 14218188.

3: RUSSELL PB. Chemistry of carphenazine. Dis Nerv Syst. 1961 Feb;22(2)Suppl:5-6. PMID: 13744855.

4: CORNEILLE HJ. ALLERGIC PURPURA IN A PATIENT TREATED WITH CARPHENAZINE. Am J Psychiatry. 1965 Feb;121:814-5. doi: 10.1176/ajp.121.8.814. PMID: 14267601.

5: OLTMAN JE, FRIEDMAN S. Carphenazine in the treatment of schizophrenia. Dis Nerv Syst. 1961 Feb;22(2)Suppl:37-41. PMID: 13730922.

6: TISLOW R. Pharmacology and toxicity of carphenazine. Dis Nerv Syst. 1961 Feb;22(2)Suppl:7-13. PMID: 13777037.

7: KOTHARI NJ, PARK IH, KLINE NS, SAUNDERS JC. Carphenazine therapy in hospitalized patients. Dis Nerv Syst. 1961 Feb;22(2)Suppl:58-9. PMID: 13753477.

8: CHEN CH, POIM S. Carphenazine in the treatment of schizophrenia. Curr Ther Res Clin Exp. 1963 Apr;5:195-7. PMID: 14020488.

9: CARTER CH. Carphenazine in mental defectives: a specific antiemetic. Arch Pediatr (N Y). 1961 Sep;78:349-56. PMID: 13691129.

10: HOSKO MJ Jr. EEG effects of carphenazine. Dis Nerv Syst. 1961 Feb;22(2)Suppl:14-8. PMID: 13716073.

11: Hanenson I. Carphenazine in the intensive care of chronically ill psychotics. Int J Neuropsychiatry. 1967 Aug;3(4):332-6. PMID: 4863506.

12: BRONSKY I. CARPHENAZINE THERAPY OF ACUTELY PSYCHOTIC PATIENTS IN THE PSYCHIATRIC WARD OF A GENERAL HOSPITAL. Am J Psychiatry. 1965 Jun;121:1203-4. doi: 10.1176/ajp.121.12.1203. PMID: 14286057.

13: Orzack MH, Kornetsky C, Freeman H. The effects of daily administration of carphenazine on attention in the schizophrenic patient. Psychopharmacologia. 1967;11(1):31-8. doi: 10.1007/BF00401506. PMID: 4876301.

14: WELSH AL. THE NEWER TRANQUILIZING DRUGS. Med Clin North Am. 1964 Mar;48:459-81. doi: 10.1016/s0025-7125(16)33476-9. PMID: 14149245.

15: Vinar O, Formánková M, Taussigová D, Růzicka S. Carphenazine in the treatment of schizophrenic psychoses. Controlled clinical trial. Act Nerv Super (Praha). 1967 Nov;9(4):353-5. PMID: 4889058.

16: BARSA JA, SAUNDERS JC. Carphenazine in the treatment of chronic schizophrenics. Am J Psychiatry. 1962 Aug;119:169. doi: 10.1176/ajp.119.2.169. PMID: 13865331.

17: TIANGCO E. Intensive hepatological studies using carphenazine. Am J Psychiatry. 1962 Mar;118:845-6. doi: 10.1176/ajp.118.9.845. PMID: 13921145.

18: FOX V. Carphenazine in the withdrawal phase of acute alcoholism. J Med Assoc Ga. 1963 Apr;52:167-70. PMID: 13959058.

19: NIVER EO. Carphenazine and the extrapyramidal regulation of kinesthetic function. Dis Nerv Syst. 1962 Jun;23:340-8. PMID: 14480089.

20: SIMS W. QUALITATIVE AND QUANTITATIVE TESTS FOR CARPHENAZINE MALEATE. J Pharm Sci. 1964 Jan;53:101-3. doi: 10.1002/jps.2600530121. PMID: 14106361.

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