WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 463319
Description: nTRD22 is a novel Allosteric Modulator of RNA Binding Targeting the N-Terminal Domain of TDP-43.
MedKoo Cat#: 463319
Chemical Formula: C19H22F3N3O4
Exact Mass: 413.1562
Molecular Weight: 413.3972
Elemental Analysis: C, 55.20; H, 5.36; F, 13.79; N, 10.16; O, 15.48
This product is not in stock, which may be available by custom synthesis.
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Synonym: nTRD22; nTRD 22; nTRD-22;
IUPAC/Chemical Name: N-(2-(3-hydroxypiperidin-1-yl)ethyl)-5-((3-(trifluoromethyl)phenoxy)methyl)isoxazole-3-carboxamide
InChi Key: SOUBULALAAVDBB-UHFFFAOYSA-N
InChi Code: InChI=1S/C19H22F3N3O4/c20-19(21,22)13-3-1-5-15(9-13)28-12-16-10-17(24-29-16)18(27)23-6-8-25-7-2-4-14(26)11-25/h1,3,5,9-10,14,26H,2,4,6-8,11-12H2,(H,23,27)
SMILES Code: O=C(C1=NOC(COC2=CC=CC(C(F)(F)F)=C2)=C1)NCCN3CC(O)CCC3
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 413.3972 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Mollasalehi N, Francois-Moutal L, Scott DD, Tello JA, Williams H, Mahoney B, Carlson JM, Dong Y, Li X, Miranda VG, Gokhale V, Wang W, Barmada SJ, Khanna M. An Allosteric Modulator of RNA Binding Targeting the N-Terminal Domain of TDP-43 Yields Neuroprotective Properties. ACS Chem Biol. 2020 Oct 12. doi: 10.1021/acschembio.0c00494. Epub ahead of print. PMID: 33044808.