nTRD22

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MedKoo CAT#: 463319

CAS#: 1065567-62-5

Description: nTRD22 is a novel Allosteric Modulator of RNA Binding Targeting the N-Terminal Domain of TDP-43. nTRD22 caused allosteric modulation of the RNA binding domain (RRM) of TDP-43, resulting in decreased binding to RNA in vitro. Moreover, incubation of primary motor neurons with nTRD22 induced a reduction of TDP-43 protein levels, similar to TDP-43 RNA binding-deficient mutants and supporting a disruption of TDP-43 binding to RNA. Finally, nTRD22 mitigated motor impairment in a Drosophila model of amyotrophic lateral sclerosis.

Chemical Structure

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nTRD22
CAS# 1065567-62-5
Instruction

Theoretical Analysis

MedKoo Cat#: 463319
Name: nTRD22
CAS#: 1065567-62-5
Chemical Formula: C19H22F3N3O4
Exact Mass: 413.16
Molecular Weight: 413.397
Elemental Analysis: C, 55.20; H, 5.36; F, 13.79; N, 10.16; O, 15.48

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: nTRD22; nTRD 22; nTRD-22;

IUPAC/Chemical Name: N-(2-(3-hydroxypiperidin-1-yl)ethyl)-5-((3-(trifluoromethyl)phenoxy)methyl)isoxazole-3-carboxamide

InChi Key: SOUBULALAAVDBB-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H22F3N3O4/c20-19(21,22)13-3-1-5-15(9-13)28-12-16-10-17(24-29-16)18(27)23-6-8-25-7-2-4-14(26)11-25/h1,3,5,9-10,14,26H,2,4,6-8,11-12H2,(H,23,27)

SMILES Code: O=C(C1=NOC(COC2=CC=CC(C(F)(F)F)=C2)=C1)NCCN3CC(O)CCC3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 413.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Mollasalehi N, Francois-Moutal L, Scott DD, Tello JA, Williams H, Mahoney B, Carlson JM, Dong Y, Li X, Miranda VG, Gokhale V, Wang W, Barmada SJ, Khanna M. An Allosteric Modulator of RNA Binding Targeting the N-Terminal Domain of TDP-43 Yields Neuroprotective Properties. ACS Chem Biol. 2020 Oct 12. doi: 10.1021/acschembio.0c00494. Epub ahead of print. PMID: 33044808.