WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 463316
Description: GAC0001E5 is a novel LXR inverse agonist, functioning as LXR a "degrader", significantly reducing LXR protein levels in PDAC cell lines.
MedKoo Cat#: 463316
Chemical Formula: C20H24N2O3
Exact Mass: 340.1787
Molecular Weight: 340.423
Elemental Analysis: C, 70.57; H, 7.11; N, 8.23; O, 14.10
This product is not in stock, which may be available by custom synthesis.
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Synonym: GAC0001E5; GAC 0001E5; GAC-0001E5;
IUPAC/Chemical Name: (3,5-dimethoxyphenyl)(4-(o-tolyl)piperazin-1-yl)methanone
InChi Key: YOXCWYCROVRVBS-UHFFFAOYSA-N
InChi Code: InChI=1S/C20H24N2O3/c1-15-6-4-5-7-19(15)21-8-10-22(11-9-21)20(23)16-12-17(24-2)14-18(13-16)25-3/h4-7,12-14H,8-11H2,1-3H3
SMILES Code: O=C(C1=CC(OC)=CC(OC)=C1)N2CCN(C3=CC=CC=C3C)CC2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 340.423 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Karaboga H, Huang W, Srivastava S, Widmann S, Addanki S, Gamage KT, Mazhar Z, Ebalunode JO, Briggs JM, Gustafsson JÅ, Filgueira CS, Gilbertson SR, Lin CY. Screening of Focused Compound Library Targeting Liver X Receptors in Pancreatic Cancer Identified Ligands with Inverse Agonist and Degrader Activity. ACS Chem Biol. 2020 Oct 19. doi: 10.1021/acschembio.0c00546. Epub ahead of print. PMID: 33074669.