WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 463315
Description: GAC0003A4 is a novel LXR inverse agonist, functioning as LXR a "degrader", significantly reducing LXR protein levels in PDAC cell lines.
MedKoo Cat#: 463315
Chemical Formula: C17H12F3N3O
Exact Mass: 331.0932
Molecular Weight: 331.2982
Elemental Analysis: C, 61.63; H, 3.65; F, 17.20; N, 12.68; O, 4.83
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Synonym: GAC0003A4; GAC 0003A4; GAC-0003A4;
IUPAC/Chemical Name: 6-phenyl-2-((3-(trifluoromethyl)phenyl)amino)pyrimidin-4(3H)-one
InChi Key: NKINUPRRPNHKNN-UHFFFAOYSA-N
InChi Code: InChI=1S/C17H12F3N3O/c18-17(19,20)12-7-4-8-13(9-12)21-16-22-14(10-15(24)23-16)11-5-2-1-3-6-11/h1-10H,(H2,21,22,23,24)
SMILES Code: O=C1NC(NC2=CC=CC(C(F)(F)F)=C2)=NC(C3=CC=CC=C3)=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 331.2982 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Karaboga H, Huang W, Srivastava S, Widmann S, Addanki S, Gamage KT, Mazhar Z, Ebalunode JO, Briggs JM, Gustafsson JÅ, Filgueira CS, Gilbertson SR, Lin CY. Screening of Focused Compound Library Targeting Liver X Receptors in Pancreatic Cancer Identified Ligands with Inverse Agonist and Degrader Activity. ACS Chem Biol. 2020 Oct 19. doi: 10.1021/acschembio.0c00546. Epub ahead of print. PMID: 33074669.