WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 412323
CAS#: 153871-75-1
Description: Carboxyebselen is a nitric oxide synthase inhibitor.
MedKoo Cat#: 412323
Name: Carboxyebselen
CAS#: 153871-75-1
Chemical Formula: C14H9NO3Se
Exact Mass: 318.9748
Molecular Weight: 318.19
Elemental Analysis: C, 52.85; H, 2.85; N, 4.40; O, 15.08; Se, 24.82
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Synonym: Carboxyebselen
IUPAC/Chemical Name: 2-(4-Carboxyphenyl)-1,2-benzisoselenazol-3(2H)-one
InChi Key: FOEPTYDLLXMPLJ-UHFFFAOYSA-N
InChi Code: InChI=1S/C14H9NO3Se/c16-13-11-3-1-2-4-12(11)19-15(13)10-7-5-9(6-8-10)14(17)18/h1-8H,(H,17,18)
SMILES Code: O=C1N(C2=CC=C(C(O)=O)C=C2)[Se]C3=C1C=CC=C3
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 318.19 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Hatchett RJ, Gryglewski RJ, Młochowski J, Zembowicz A, Radziszewski W. Carboxyebselen a potent and selective inhibitor of endothelial nitric oxide synthase. J Physiol Pharmacol. 1994 Mar;45(1):55-67. PMID: 7519084.
2: Cai W, Wu J, Xi C, Ashe AJ 3rd, Meyerhoff ME. Carboxyl-ebselen-based layer- by-layer films as potential antithrombotic and antimicrobial coatings. Biomaterials. 2011 Nov;32(31):7774-84. doi: 10.1016/j.biomaterials.2011.06.075. Epub 2011 Jul 26. PMID: 21794909; PMCID: PMC3159861.