Carboprost

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 412320

CAS#: 35700-23-3

Description: Carboprost a nonsteroidal abortifacient agent that is effective in both the first and second trimesters of PREGNANCY.


Chemical Structure

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Carboprost
CAS# 35700-23-3

Theoretical Analysis

MedKoo Cat#: 412320
Name: Carboprost
CAS#: 35700-23-3
Chemical Formula: C21H36O5
Exact Mass: 368.2563
Molecular Weight: 368.51
Elemental Analysis: C, 68.45; H, 9.85; O, 21.71

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Carboprost; U-32921; U32921; U 32921

IUPAC/Chemical Name: Prosta-5,13-dien-1-oic acid, 9,11,15-trihydroxy-15-methyl-, (5Z,9alpha,11alpha,13E,15S)-

InChi Key: DLJKPYFALUEJCK-IIELGFQLSA-N

InChi Code: InChI=1S/C21H36O5/c1-3-4-9-13-21(2,26)14-12-17-16(18(22)15-19(17)23)10-7-5-6-8-11-20(24)25/h5,7,12,14,16-19,22-23,26H,3-4,6,8-11,13,15H2,1-2H3,(H,24,25)/b7-5-,14-12+/t16-,17-,18+,19-,21+/m1/s1

SMILES Code: CCCCC[C@](C)(O)/C=C/[C@@H]1[C@H]([C@@H](O)C[C@H]1O)C/C=C\CCCC(O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 368.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Vallera C, Choi LO, Cha CM, Hong RW. Uterotonic Medications: Oxytocin, Methylergonovine, Carboprost, Misoprostol. Anesthesiol Clin. 2017 Jun;35(2):207-219. doi: 10.1016/j.anclin.2017.01.007. Epub 2017 Mar 30. PMID: 28526143.

2: Ling Z, Yao L, Cui Z, Lifan C. Effect of carboprost tromethamine in prevention of postpartum hemorrhage in cesarean section. Pak J Pharm Sci. 2018 Sep;31(5(Special)):2257-2262. PMID: 30463821.

3: Meng W, Li R, Zha N, E L. Efficacy and safety of motherwort injection add-on therapy to carboprost tromethamine for prevention of post-partum blood loss: A meta-analysis of randomized controlled trials. J Obstet Gynaecol Res. 2019 Jan;45(1):47-56. doi: 10.1111/jog.13833. Epub 2018 Oct 4. PMID: 30288846.

4: Zhang R, Shi H, Ren F, Yuan Z. Assessment of carboprost tromethamine for reducing hemorrhage in laparoscopic intramural myomectomy. Exp Ther Med. 2015 Sep;10(3):1171-1174. doi: 10.3892/etm.2015.2649. Epub 2015 Jul 20. PMID: 26622459; PMCID: PMC4533125.

5: Duan H, Hao M, Wang SM, Meng YJ, Wang Y, Yuan R, Xue X, Yang Q, Lin J, He YL, Shi YL, Liu JH, Wang X, Wang S. [Clinical multicenter study of carboprost methylate suppository for cervical ripening prior to diagnostic hysteroscopy]. Zhonghua Fu Chan Ke Za Zhi. 2018 Sep 25;53(9):602-607. Chinese. doi: 10.3760/cma.j.issn.0529-567x.2018.09.004. PMID: 30293295.

6: Sunil Kumar KS, Shyam S, Batakurki P. Carboprost Versus Oxytocin for Active Management of Third Stage of Labor: A Prospective Randomized Control Study. J Obstet Gynaecol India. 2016 Oct;66(Suppl 1):229-34. doi: 10.1007/s13224-016-0842-x. Epub 2016 Mar 22. PMID: 27651609; PMCID: PMC5016447.

7: Mozurkewich EL, Chilimigras JL, Berman DR, Perni UC, Romero VC, King VJ, Keeton KL. Methods of induction of labour: a systematic review. BMC Pregnancy Childbirth. 2011 Oct 27;11:84. doi: 10.1186/1471-2393-11-84. PMID: 22032440; PMCID: PMC3224350.

8: Yin L, Meng X, Zhou X, Zhang T, Sun H, Yang Z, Yang B, Xiao N, Fawcett JP, Yang Y, Gu J. Simultaneous determination of carboprost methylate and its active metabolite carboprost in dog plasma by liquid chromatography-tandem mass spectrometry with positive/negative ion-switching electrospray ionization and its application to a pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Aug 15;998-999:8-14. doi: 10.1016/j.jchromb.2015.05.039. Epub 2015 Jun 25. PMID: 26149245.

9: Bai J, Sun Q, Zhai H. A comparison of oxytocin and carboprost tromethamine in the prevention of postpartum hemorrhage in high-risk patients undergoing cesarean delivery. Exp Ther Med. 2014 Jan;7(1):46-50. doi: 10.3892/etm.2013.1379. Epub 2013 Nov 1. PMID: 24348762; PMCID: PMC3861477.

10: Balki M, Erik-Soussi M, Ramachandran N, Kingdom J, Carvalho JC. The Contractile Effects of Oxytocin, Ergonovine, and Carboprost and Their Combinations: an In Vitro Study on Human Myometrial Strips. Anesth Analg. 2015 May;120(5):1074-84. doi: 10.1213/ANE.0000000000000682. PMID: 25822922.