Carbocysteine lysine

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 412309

CAS#: 49673-81-6

Description: Carbocysteine lysine dipeptide biochemical


Chemical Structure

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Carbocysteine lysine
CAS# 49673-81-6

Theoretical Analysis

MedKoo Cat#: 412309
Name: Carbocysteine lysine
CAS#: 49673-81-6
Chemical Formula: C11H23N3O6S
Exact Mass: 325.1308
Molecular Weight: 325.38
Elemental Analysis: C, 40.61; H, 7.13; N, 12.91; O, 29.50; S, 9.85

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Carbocysteine lysine; EINECS 256-425-9; UNII-1D1Y95PXXA

IUPAC/Chemical Name: L-Lysine, compound with S-(carboxymethyl)-L-cysteine (1:1)

InChi Key: SAGXGPWVLUSDSQ-RVZXSAGBSA-N

InChi Code: InChI=1S/C6H14N2O2.C5H9NO4S/c7-4-2-1-3-5(8)6(9)10;6-3(5(9)10)1-11-2-4(7)8/h5H,1-4,7-8H2,(H,9,10);3H,1-2,6H2,(H,7,8)(H,9,10)/t5-;3-/m00/s1

SMILES Code: N[C@@H](CCCCN)C(O)=O.N[C@@H](CSCC(O)=O)C(O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 325.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Paone G, Lanata L, Saibene F, Toti S, Palermo P, Graziani C, Flore MC, Ramaccia M, Puglisi G. A prospective study of the effects of carbocysteine lysine salt on frequency of exacerbations in COPD patients treated with or without inhaled steroids. Eur Rev Med Pharmacol Sci. 2019 Aug;23(15):6727-6735. doi: 10.26355/eurrev_201908_18564. PMID: 31378916.

2: Brandolini L, Allegretti M, Berdini V, Cervellera MN, Mascagni P, Rinaldi M, Melillo G, Ghezzi P, Mengozzi M, Bertini R. Carbocysteine lysine salt monohydrate (SCMC-LYS) is a selective scavenger of reactive oxygen intermediates (ROIs). Eur Cytokine Netw. 2003 Jan-Mar;14(1):20-6. PMID: 12799210.

3: Biswas S, Hwang JW, Kirkham PA, Rahman I. Pharmacological and dietary antioxidant therapies for chronic obstructive pulmonary disease. Curr Med Chem. 2013;20(12):1496-530. doi: 10.2174/0929867311320120004. PMID: 22963552.

4: Pinamonti S, Venturoli L, Leis M, Chicca M, Barbieri A, Sostero S, Ravenna F, Daffonchio L, Novellini R, Ciaccia A. Antioxidant activity of carbocysteine lysine salt monohydrate. Panminerva Med. 2001 Sep;43(3):215-20. PMID: 11579333.

5: Asti C, Melillo G, Caselli GF, Daffonchio L, Hernandez A, Clavenna G, Omini C. Effectiveness of carbocysteine lysine salt monohydrate on models of airway inflammation and hyperresponsiveness. Pharmacol Res. 1995 Jun;31(6):387-92. doi: 10.1016/1043-6618(95)80094-8. PMID: 8685078.

6: Carpagnano GE, Resta O, Foschino-Barbaro MP, Spanevello A, Stefano A, Di Gioia G, Serviddio G, Gramiccioni E. Exhaled Interleukine-6 and 8-isoprostane in chronic obstructive pulmonary disease: effect of carbocysteine lysine salt monohydrate (SCMC-Lys). Eur J Pharmacol. 2004 Nov 28;505(1-3):169-75. doi: 10.1016/j.ejphar.2004.10.007. PMID: 15556150.

7: Caramia G, Gagliardini R, Ruffini E, Osimani P, Nobilini A. The management of cystic fibrosis with carbocysteine lysine salt: single-blind comparative study with ambroxol hydrochloride. J Int Med Res. 1995 Jul-Aug;23(4):284-93. doi: 10.1177/030006059502300409. PMID: 7589772.

8: Meyer G, Doppierio S, Daffonchio L, Cremaschi D. S-carbocysteine-lysine salt monohydrate and cAMP cause non-additive activation of the cystic fibrosis transmembrane regulator channel in human respiratory epithelium. FEBS Lett. 1997 Mar 3;404(1):11-4. doi: 10.1016/s0014-5793(97)00074-4. PMID: 9074627.

9: Mitchell SC, Steventon GB. Phenylalanine 4-monooxygenase: the "sulfoxidation polymorphism". Xenobiotica. 2020 Jan;50(1):51-63. doi: 10.1080/00498254.2019.1636419. Epub 2019 Jul 12. PMID: 31233370.

10: Braga PC, Allegra L, Rampoldi C, Ornaghi A, Beghi G. Long-lasting effects on rheology and clearance of bronchial mucus after short-term administration of high doses of carbocysteine-lysine to patients with chronic bronchitis. Respiration. 1990;57(6):353-8. doi: 10.1159/000195871. PMID: 2099568.