Zoledronate disodium hydrate

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MedKoo CAT#: 574949

CAS#: 165800-07-7 (disodium hydrate)

Description: Zoledronate disodium hydrate, also known as Zoledronic Acid Disodium Salt Tetrahydrate, is a biphosphonate bone resorption inhibitor.

Chemical Structure

Zoledronate disodium hydrate
CAS# 165800-07-7 (disodium hydrate)

Theoretical Analysis

MedKoo Cat#: 574949
Name: Zoledronate disodium hydrate
CAS#: 165800-07-7 (disodium hydrate)
Chemical Formula: C5H16N2Na2O11P2
Exact Mass: 0.00
Molecular Weight: 388.113
Elemental Analysis: C, 15.47; H, 4.16; N, 7.22; Na, 11.85; O, 45.34; P, 15.96

Price and Availability

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1g USD 3650 4-6 weeks
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Related CAS #: 118072-93-8 (free acid)   165800-06-6 (free acid hydrate)   131654-46-1 (disodium)   827573-11-5 (trisodium)   165800-07-7 (disodium hydrate)   165800-08-8 (trisodium hydrate)    

Synonym: Zoledronic Acid Disodium Salt Tetrahydrate; Zoledronate Disodium, Zoledronate disodium hydrate; CGP-42446A; CGP 42446A; CGP42446A;

IUPAC/Chemical Name: Phosphonic acid, (1-hydroxy-2-(1H-imidazol-1-yl)ethylidene)bis-, disodium salt, tetrahydrate


InChi Code: InChI=1S/C5H10N2O7P2.2Na.4H2O/c8-5(15(9,10)11,16(12,13)14)3-7-2-1-6-4-7;;;;;;/h1-2,4,8H,3H2,(H2,9,10,11)(H2,12,13,14);;;4*1H2/q;2*+1;;;;/p-2

SMILES Code: OC(P([O-])([O-])=O)(P(O)(O)=O)CN1C=CN=C1.[H]O[H].[H]O[H].[H]O[H].[H]O[H].[Na+].[Na+]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 388.11 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Hortobagyi GN, Van Poznak C, Harker WG, Gradishar WJ, Chew H, Dakhil SR, Haley BB, Sauter N, Mohanlal R, Zheng M, Lipton A. Continued Treatment Effect of Zoledronic Acid Dosing Every 12 vs 4 Weeks in Women With Breast Cancer Metastatic to Bone: The OPTIMIZE-2 Randomized Clinical Trial. JAMA Oncol. 2017 Jul 1;3(7):906-912. doi: 10.1001/jamaoncol.2016.6316. PMID: 28125763; PMCID: PMC5824238.