WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 412268
CAS#: 150956-50-6
Description: Canventol inhibits tumor necrosis factor alpha release and protein isoprenylation
MedKoo Cat#: 412268
Name: Canventol
CAS#: 150956-50-6
Chemical Formula: C12H20O
Exact Mass: 180.1514
Molecular Weight: 180.29
Elemental Analysis: C, 79.94; H, 11.18; O, 8.87
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Synonym: Canventol; DL-Canventol
IUPAC/Chemical Name: 2-Cyclohexen-1-ol, 2-(1-methylethyl)-4-(1-methylethylidene)-, (+-)-
InChi Key: CYOJESZRZNCQEV-UHFFFAOYSA-N
InChi Code: InChI=1S/C12H20O/c1-8(2)10-5-6-12(13)11(7-10)9(3)4/h7,9,12-13H,5-6H2,1-4H3
SMILES Code: OC1C(C(C)C)=C/C(CC1)=C(C)\C
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 180.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Yun TK. Update from Asia. Asian studies on cancer chemoprevention. Ann N Y Acad Sci. 1999;889:157-92. doi: 10.1111/j.1749-6632.1999.tb08734.x. PMID: 10668493.
2: Biswas DK, Mhashilkar AM, Ewaniuk DS, Pezza JA, Oh LM, Kannangara GS, Tius MA, Pardee AB. Inhibition of HIV-1 replication by combination of a novel inhibitor of TNF-alpha with AZT. J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Aug 15;18(5):426-34. doi: 10.1097/00042560-199808150-00003. PMID: 9715838.
3: Komori A, Okabe S, Suganuma M, Kerr MA, Busch-Petersen J, Oh LM, Zhuo J, Kannangara GS, Zou X, Tius MA, Fujiki H. Anti-tumor promoting activity of canventol and its synthetic analogs through inhibition of protein isoprenylation. Jpn J Cancer Res. 1996 Sep;87(9):875-81. doi: 10.1111/j.1349-7006.1996.tb02114.x. PMID: 8878447; PMCID: PMC5921199.
4: Suganuma M, Okabe S, Sueoka E, Iida N, Komori A, Kim SJ, Fujiki H. A new process of cancer prevention mediated through inhibition of tumor necrosis factor alpha expression. Cancer Res. 1996 Aug 15;56(16):3711-5. PMID: 8706012.
5: Biswas DK, Tius MA, Zhuo J, Pardee AB. Canventol inhibits HIV-1 replication by Tat-induced Tar-independent mechanism. J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Jun 1;12(2):120-7. doi: 10.1097/00042560-199606010-00004. PMID: 8680882.
6: Fujiki H, Suganuma M, Komori A, Yatsunami J, Okabe S, Ohta T, Sueoka E. A new tumor promotion pathway and its inhibitors. Cancer Detect Prev. 1994;18(1):1-7. PMID: 8162603.
7: Komori A, Suganuma M, Okabe S, Zou X, Tius MA, Fujiki H. Canventol inhibits tumor promotion in CD-1 mouse skin through inhibition of tumor necrosis factor alpha release and of protein isoprenylation. Cancer Res. 1993 Aug 1;53(15):3462-4. PMID: 8339247.
