WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 535751
CAS#: 42207-96-5
Description: MB 3 is a biaoctive chemical.
MedKoo Cat#: 535751
Name: MB 3
CAS#: 42207-96-5
Chemical Formula: C22H29ClN4O3S
Exact Mass: 464.1649
Molecular Weight: 465.009
Elemental Analysis: C, 56.83; H, 6.29; Cl, 7.62; N, 12.05; O, 10.32; S, 6.89
This product is not in stock, which may be available by custom synthesis.
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Synonym: MB 3; MB-3; MB3
IUPAC/Chemical Name: N-((4-Amino-2-methyl-5-pyrimidinyl)methyl)-N-(4-hydroxy-1-methyl-2-((3-(4-methylphenyl)-3-oxopropyl)thio)-1-butenyl)formamide, monohydrochloride
InChi Key: ZJZCTCNQTXBBFZ-JEBHESKQSA-N
InChi Code: InChI=1S/C22H28N4O3S.ClH/c1-15-4-6-18(7-5-15)20(29)9-11-30-21(8-10-27)16(2)26(14-28)13-19-12-24-17(3)25-22(19)23;/h4-7,12,14,27H,8-11,13H2,1-3H3,(H2,23,24,25);1H/b21-16+;
SMILES Code: O=CN(CC1=CN=C(C)N=C1N)/C(C)=C(SCCC(C2=CC=C(C)C=C2)=O)\CCO.[H]Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 465.009 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
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4: Gruberg L, Mehran R, Waksman R, Dangas G, Fuchs S, Wu H, Kent KM, Pichard AD, Satler LF, Stone GW, Leon MB. Creatine kinase-MB fraction elevation after percutaneous coronary intervention in patients with chronic renal failure. Am J Cardiol. 2001 Jun 15;87(12):1356-60. doi: 10.1016/s0002-9149(01)01552-1. PMID: 11397353.
5: Chen J, Jiang Z, Zhou X, Sun X, Cao J, Liu Y, Wang X. Dexmedetomidine Preconditioning Protects Cardiomyocytes Against Hypoxia/Reoxygenation-Induced Necroptosis by Inhibiting HMGB1-Mediated Inflammation. Cardiovasc Drugs Ther. 2019 Feb;33(1):45-54. doi: 10.1007/s10557-019-06857-1. PMID: 30675709.
6: Testa S, Legnani C, Antonucci E, Paoletti O, Dellanoce C, Cosmi B, Pengo V, Poli D, Morandini R, Testa R, Tripodi A, Palareti G; Coordinator of START2-Register. Drug levels and bleeding complications in atrial fibrillation patients treated with direct oral anticoagulants. J Thromb Haemost. 2019 Jul;17(7):1064-1072. doi: 10.1111/jth.14457. Epub 2019 May 26. PMID: 31013383; PMCID: PMC6852698.
7: Chen XM, Ma N, Zhang QF, Wang J, Feng X, Wei C, Wang LS, Zhang J, Chen X. Elucidation of the Formation Mechanisms of the Octahydrotriborate Anion (B3H8-) through the Nucleophilicity of the B-H Bond. J Am Chem Soc. 2018 May 30;140(21):6718-6726. doi: 10.1021/jacs.8b03785. Epub 2018 May 16. PMID: 29732884.
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9: Yang Y, Meyer CH, Epstein FH, Kramer CM, Salerno M. Whole-heart spiral simultaneous multi-slice first-pass myocardial perfusion imaging. Magn Reson Med. 2019 Feb;81(2):852-862. doi: 10.1002/mrm.27412. Epub 2018 Oct 12. PMID: 30311689; PMCID: PMC6289615.
10: Luo Y, Jia B, Yan K, Liu S, Song X, Chen M, Jin F, Du Y, Wang J, Hong Y, Cao S, Li D, Dong M. Pilot study of a novel multi-functional noninvasive prenatal test on fetus aneuploidy, copy number variation, and single-gene disorder screening. Mol Genet Genomic Med. 2019 Apr;7(4):e00597. doi: 10.1002/mgg3.597. Epub 2019 Feb 14. PMID: 30767419; PMCID: PMC6465655.
