Candocuronium iodide

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 412261

CAS#: 54278-85-2

Description: Candocuronium iodide is an aminosteroid neuromuscular-blocking drug or skeletal muscle relaxant in the category of non-depolarizing neuromuscular-blocking drugs. Its potential adjunctive use in anesthesia to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation was briefly evaluated in clinical studies in India, but further development discontinued because of attendant cardiovascular effects, primarily tachycardia that was no worse than but also not an improvement over the clinically established pancuronium bromide. Candocuronium demonstrated a short duration and a rapid onset of action, with little or no ganglion blocking activity, and it was only slightly less potent than pancuronium.

Chemical Structure

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Candocuronium iodide
CAS# 54278-85-2

Theoretical Analysis

MedKoo Cat#: 412261
Name: Candocuronium iodide
CAS#: 54278-85-2
Chemical Formula: C26H46I2N2
Exact Mass: 640.175
Molecular Weight: 640.47
Elemental Analysis: C, 48.76; H, 7.24; I, 39.63; N, 4.37

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales or click below button.
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Synonym: Candocuronium iodide; HS310; HS 310; HS-310

IUPAC/Chemical Name: (4aS,4bR,8S,10aR,10bS,12aS)-1,1,10a,12a-tetramethyl-8-(1-methylpyrrolidin-1-ium-1-yl)-1,2,3,4,4a,4b,5,7,8,9,10,10a,10b,11,12,12a-hexadecahydronaphtho[2,1-f]quinolin-1-ium iodide


InChi Code: InChI=1S/C26H46N2.2HI/c1-25-14-12-21(28(5)17-6-7-18-28)19-20(25)10-11-22-23(25)13-15-26(2)24(22)9-8-16-27(26,3)4;;/h10,21-24H,6-9,11-19H2,1-5H3;2*1H/q+2;;/p-2/t21-,22+,23-,24-,25-,26-;;/m0../s1

SMILES Code: C[C@]12CC[C@H]([N+]3(CCCC3)C)CC1=CC[C@@H]4[C@@H]2CC[C@]5([C@H]4CCC[N+]5(C)C)C.[I-].[I-]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 640.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Jindal DP, Piplani P, Fajrak H, Prior C, Marshall IG. Synthesis and neuromuscular blocking activity of 16beta-piperidinosteroidal derivatives. Eur J Med Chem. 2001 Feb;36(2):195-202. doi: 10.1016/s0223-5234(00)01205-8. PMID: 11311750.

2: Suri YV, Nayak BB, Jaiprakash M. HISTAMINE RELEASE AND CHANDONIUM IODIDE. Med J Armed Forces India. 1996 Oct;52(4):245-247. doi: 10.1016/S0377-1237(17)30877-8. Epub 2017 Jun 26. PMID: 28769406; PMCID: PMC5530797.

3: Suri YV, Tripathi PC, Srimal RC, Gaur S, Dhawan BN. DOSE RESPONSE RELATIONSHIP OF NEUROMUSCULAR BLOCKADE, INTUBATION CONDITIONS AND CARDIOVASCULAR CHANGES WITH CHANDONIUM IODIDE. Med J Armed Forces India. 1994 Jan;50(1):37-43. doi: 10.1016/S0377-1237(17)31036-5. Epub 2017 Jun 27. PMID: 28769159; PMCID: PMC5529698.

4: Kumar D, Bhatia VK, Yajnik S, Gaur SP, Nityanand S. Clinical evaluation of chandonium iodide as a nondepolarising muscle relaxant. Indian J Med Res. 1990 Oct;92:367-70. PMID: 2148735.

5: Dasgupta D, Gupta KC, Vispute AV, Karandikar SM. Comparative clinical evaluation of chandonium iodide and pancuronium bromide as muscle relaxant. J Postgrad Med. 1990 Apr;36(2):95-9. PMID: 2151453.

6: Dasgupta D, D'Souza M, Shah SJ, Gupta KC, Satoskar RS. Clinical evaluation of chandonium iodide as muscle relaxant. Indian J Med Res. 1988 Mar;87:298-302. PMID: 3397166.

7: Bokisch AJ, Hussain J, Palmer RA, Walker RJ. The antagonism of acetylcholine excitatory and inhibitory responses of Helix central neurones, by some neuromuscular blocking drugs. Eur J Pharmacol. 1985 Jun 19;112(3):405-9. doi: 10.1016/0014-2999(85)90788-5. PMID: 4018142.

8: Singh H, Chaudhary AK. Assay, formulation and stability of chandonium iodide. Indian J Exp Biol. 1985 May;23(5):265-6. PMID: 4077125.

9: Singh H, Chaudhary AK. Protein binding studies with chandonium iodide. Indian J Exp Biol. 1985 May;23(5):262-4. PMID: 4077124.

10: Singh H, Chaudhary AK. Pharmacokinetics and disposition of chandonium iodide in monkey. Indian J Exp Biol. 1985 May;23(5):258-61. PMID: 4077123.

11: Singh H, Chaudhary AK. Pharmacokinetics and disposition of chandonium iodide in rat. Indian J Exp Biol. 1985 May;23(5):253-7. PMID: 4077122.

12: Suri YV, Singh D, Mukherjee KC, Raghubir R, Srimal RC, Dhawan BN. Effects of some antimicrobial agents on neuromuscular blocking activity of chandonium iodide. Indian J Exp Biol. 1984 Aug;22(8):428-31. PMID: 6510976.

13: Harvey AL, Paul D, Rodger IW, Singh H. Actions of the muscle relaxant chandonium iodide on guinea-pig ileum and vas deferens preparations. J Pharm Pharmacol. 1976 Aug;28(8):617-9. doi: 10.1111/j.2042-7158.1976.tb02812.x. PMID: 11309.

14: Harvey AL, Paul D, Singh H. Proceedings: Actions of chandonium iodide on skeletal muscle in culture. J Pharm Pharmacol. 1975 Dec;27 Suppl?-2:62P. PMID: 2738.

15: Gandiha A, Marshall IG, Paul D, Rodger IW, Scott W, Singh H. Some actions of chandonium iodide, a new short-acting muscle relaxant, in anaesthetized cats and on isolated muscle preparations. Clin Exp Pharmacol Physiol. 1975 Mar- Apr;2(2):159-70. doi: 10.1111/j.1440-1681.1975.tb01830.x. PMID: 237641.

16: Singh H, Paul D. Steroids and related studies. XXV. Chandonium iodide (17a-methyl-3beta-pyrrolidino-17a-aza-D-homoandrost-5-ene dimethiodide) and other quaternary ammonium steroid analogues. J Chem Soc Perkin 1. 1974;0(12):1475-9. doi: 10.1039/p19740001475. PMID: 4472321.