WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 412243

CAS#: 548-27-6

Description: Calophyllolid is a neoflavonoid is anti-inflammtory and wound healing activities

Chemical Structure

CAS# 548-27-6

Theoretical Analysis

MedKoo Cat#: 412243
Name: Calophyllolid
CAS#: 548-27-6
Chemical Formula: C26H24O5
Exact Mass: 416.1624
Molecular Weight: 416.47
Elemental Analysis: C, 74.98; H, 5.81; O, 19.21

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Calophyllolid; BRN0061648 ; BRN-0061648 ; BRN 0061648

IUPAC/Chemical Name: 2H,8H-Benzo(1,2-b,3,4-b')dipyran-8-one, 5-methoxy-2,2-dimethyl-6-(2-methylcrotonoyl)-10-phenyl-, (E)-


InChi Code: InChI=1S/C26H24O5/c1-6-15(2)22(28)21-23(29-5)17-12-13-26(3,4)31-24(17)20-18(14-19(27)30-25(20)21)16-10-8-7-9-11-16/h6-14H,1-5H3/b15-6+

SMILES Code: O=C1C=C(C2=CC=CC=C2)C3=C4C(C=CC(C)(C)O4)=C(OC)C(C(/C(C)=C/C)=O)=C3O1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 416.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Nguyen VL, Truong CT, Nguyen BCQ, Vo TV, Dao TT, Nguyen VD, Trinh DT, Huynh HK, Bui CB. Anti-inflammatory and wound healing activities of calophyllolide isolated from Calophyllum inophyllum Linn. PLoS One. 2017 Oct 11;12(10):e0185674. doi: 10.1371/journal.pone.0185674. PMID: 29020015; PMCID: PMC5636079.

2: Liu WH, Liu YW, Chen ZF, Chiou WF, Tsai YC, Chen CC. Calophyllolide content in Calophyllum inophyllum at different stages of maturity and its osteogenic activity. Molecules. 2015 Jul 7;20(7):12314-27. doi: 10.3390/molecules200712314. PMID: 26198219; PMCID: PMC6332356.

3: Ma T, Wang L, Cheng GF, Liu G. Synthesis of calophyllolide analogue and its preliminary anti-inflammatory activity. Yao Xue Xue Bao. 2010 Oct;45(10):1265-9. PMID: 21344845.

4: Laure F, Raharivelomanana P, Butaud JF, Bianchini JP, Gaydou EM. Screening of anti-HIV-1 inophyllums by HPLC-DAD of Calophyllum inophyllum leaf extracts from French Polynesia Islands. Anal Chim Acta. 2008 Aug 22;624(1):147-53. doi: 10.1016/j.aca.2008.06.046. Epub 2008 Jul 9. PMID: 18706320.

5: Charles L, Laure F, Raharivelomanana P, Bianchini JP. Sheath liquid interface for the coupling of normal-phase liquid chromatography with electrospray mass spectrometry and its application to the analysis of neoflavonoids. J Mass Spectrom. 2005 Jan;40(1):75-82. doi: 10.1002/jms.777. PMID: 15584013.

6: Saxena RC, Nath R, Palit G, Nigam SK, Bhargava KP. Effect of calophyllolide, a nonsteroidal anti-inflammatory agent, on capillary permeability. Planta Med. 1982 Apr;44(4):246-8. doi: 10.1055/s-2007-971459. PMID: 7100303.

7: Bhalla TN, Saxena RC, Nigam SK, Misra G, Bhargava KP. Calophyllolide--a new non-steroidal anti-inflammatory agent. Indian J Med Res. 1980 Nov;72:762-5. PMID: 7203581.

8: Rehse K, Schnädelbach S, Rietbrock N, Gruber F. Uberprüfung der gerinnungsphysiologischen Aktivität von Calophyllolid [Evaluation of the anticoagulant activity of calophyllolid]. Arch Pharm (Weinheim). 1979 Jan;312(1):72-3. German. doi: 10.1002/ardp.19793120114. PMID: 426617.

9: Rehse K, Schnädelbach S, Rietbrock N, Gruber F. Calophyllolidanaloge Cumarinderivate [Cumarin derivatives related to calophyllolid (author's transl)]. Arch Pharm (Weinheim). 1978 Jan;311(1):52-8. German. doi: 10.1002/ardp.19783110111. PMID: 626569.

10: ARORA RB, MATHUR CN, SETH SD. Calophyllolide, a complex coumarin anticoagulant from Calophyllum inophyllum Linn. J Pharm Pharmacol. 1962 Aug;14:534-5. doi: 10.1111/j.2042-7158.1962.tb11133.x. PMID: 13862532.