Calixarene

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 412238

CAS#: 130036-26-9

Description: Calixarene is a henolic metacyclophanes derived from condensation of PHENOLS and ALDEHYDES. The name derives from the vase-like molecular structures. A bracketed [n] indicates the number of aromatic rings.


Chemical Structure

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Calixarene
CAS# 130036-26-9

Theoretical Analysis

MedKoo Cat#: 412238
Name: Calixarene
CAS#: 130036-26-9
Chemical Formula: C56H72O12
Exact Mass: 936.5024
Molecular Weight: 937.18
Elemental Analysis: C, 71.77; H, 7.74; O, 20.49

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Calixarene;

IUPAC/Chemical Name: Acetic acid, 2,2',2'',2'''-((25,26,27,28-tetrakis(1,1-dimethylethyl)pentacyclo(19.3.1.1(3,7).1(9,13).1(15,19))octacosa-1(25),3,5,7(28),9,11,13(27),15,17,19(26),21,23-dodecaene-5,11,17,23-tetrayl)tetrakis(oxy))tetrakis-, tetramethyl ester

InChi Key: RUNKYESLQRKVBG-UHFFFAOYSA-N

InChi Code: InChI=1S/C56H72O12/c1-53(2,3)49-33-17-35-23-42(66-30-46(58)62-14)25-37(50(35)54(4,5)6)19-39-27-44(68-32-48(60)64-16)28-40(52(39)56(10,11)12)20-38-26-43(67-31-47(59)63-15)24-36(51(38)55(7,8)9)18-34(49)22-41(21-33)65-29-45(57)61-13/h21-28H,17-20,29-32H2,1-16H3

SMILES Code: CC(C1=C(CC2=CC(OCC(OC)=O)=CC(CC3=CC(OCC(OC)=O)=CC(C4)=C3C(C)(C)C)=C2C(C)(C)C)C=C(OCC(OC)=O)C=C1CC5=C(C(C)(C)C)C4=CC(OCC(OC)=O)=C5)(C)C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 937.18 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Abd El-Rahman MK, Mazzone G, Mahmoud AM, Sicilia E, Shoeib T. Novel choline selective electrochemical membrane sensor with application in milk powders and infant formulas. Talanta. 2021 Jan 1;221:121409. doi: 10.1016/j.talanta.2020.121409. Epub 2020 Jul 17. PMID: 33076056.

2: Narula A, Hussain MA, Upadhyay A, Rao CP. 1,3-Di-naphthalimide Conjugate of Calix[4]arene as a Sensitive and Selective Sensor for Trinitrophenol and This Turns Reversible when Hybridized with Carrageenan as Beads. ACS Omega. 2020 Sep 29;5(40):25747-25756. doi: 10.1021/acsomega.0c03060. PMID: 33073100; PMCID: PMC7557251.

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4: Deng CL, Murkli SL, Isaacs LD. Supramolecular hosts as in vivo sequestration agents for pharmaceuticals and toxins. Chem Soc Rev. 2020 Oct 12. doi: 10.1039/d0cs00454e. Epub ahead of print. PMID: 33043945.

5: Blond P, Bevernaegie R, Troian-Gautier L, Lagrost C, Hubert J, Reniers F, Raussens V, Jabin I. Ready-to-Use Germanium Surfaces for the Development of FTIR-Based Biosensors for Proteins. Langmuir. 2020 Oct 13;36(40):12068-12076. doi: 10.1021/acs.langmuir.0c02681. Epub 2020 Oct 2. PMID: 33007158.

6: Guo H, Zhang R, Han Y, Wang J, Yan C. Corrigendum: A p-tert-Butyldihomooxacalix[4]arene Based Soft Gel for Sustained Drug Release in Water. Front Chem. 2020 Aug 21;8:721. doi: 10.3389/fchem.2020.00721. Erratum for: Front Chem. 2020 Feb 28;8:33. PMID: 32974283; PMCID: PMC7473151.

7: Muravev A, Gerasimova T, Fayzullin R, Babaeva O, Rizvanov I, Khamatgalimov A, Kadirov M, Katsyuba S, Litvinov I, Latypov S, Solovieva S, Antipin I. Thermally Stable Nitrothiacalixarene Chromophores: Conformational Study and Aggregation Behavior. Int J Mol Sci. 2020 Sep 21;21(18):6916. doi: 10.3390/ijms21186916. PMID: 32967166; PMCID: PMC7554919.

8: Zhao H, Liu F, Xie W, Zhou TC, OuYang J, Jin L, Li H, Zhao CY, Zhang L, Wei J, Zhang YP, Li CP. Ultrasensitive supersandwich-type electrochemical sensor for SARS-CoV-2 from the infected COVID-19 patients using a smartphone. Sens Actuators B Chem. 2021 Jan 15;327:128899. doi: 10.1016/j.snb.2020.128899. Epub 2020 Sep 14. PMID: 32952300; PMCID: PMC7489230.

9: Islam MM, Georghiou PE, Rahman S, Yamato T. Calix[3]arene-Analogous Metacyclophanes: Synthesis, Structures and Properties with Infinite Potential. Molecules. 2020 Sep 14;25(18):E4202. doi: 10.3390/molecules25184202. PMID: 32937796.

10: Yilmaz B, Keskinates M, Bayrakci M. Novel integrated sensing system of calixarene and rhodamine molecules for selective colorimetric and fluorometric detection of Hg2+ ions in living cells. Spectrochim Acta A Mol Biomol Spectrosc. 2020 Sep 3;245:118904. doi: 10.1016/j.saa.2020.118904. Epub ahead of print. PMID: 32932034.

11: Schäfer C, Perera PN, Laible F, Olynick DL, Schwartzberg AM, Weber-Bargioni A, Cabrini S, Schuck PJ, Kern DP, Fleischer M. Selectively accessing the hotspots of optical nanoantennas by self-aligned dry laser ablation. Nanoscale. 2020 Oct 1;12(37):19170-19177. doi: 10.1039/d0nr04024j. PMID: 32926034.

12: Uttam B, Jahan I, Sen S, Rao CP. Coumarin-Calix[4]arene Conjugate-Anchored SiO2 Nanoparticles as an Ultrasensor Material for Fe3+ to Work in Water, in Serum, and in Biological Cells. ACS Omega. 2020 Aug 12;5(33):21288-21299. doi: 10.1021/acsomega.0c03373. PMID: 32875265; PMCID: PMC7450711.

13: Shetty D, Jahović I, Skorjanc T, Erkal TS, Ali L, Raya J, Asfari Z, Olson MA, Kirmizialtin S, Yazaydin AO, Trabolsi A. Rapid and Efficient Removal of Perfluorooctanoic Acid from Water with Fluorine-Rich Calixarene-Based Porous Polymers. ACS Appl Mater Interfaces. 2020 Sep 23;12(38):43160-43166. doi: 10.1021/acsami.0c13400. Epub 2020 Sep 10. PMID: 32851843.

14: Spadaro A, Basile L, Pappalardo M, Bonaccorso C, Rao M, Ronsisvalle S, Granata G, Guccione S. Quantum Chemical and Molecular Dynamics Studies of MUC1 Calix[4,8]arene Scaffold Based Anticancer Vaccine Candidates. J Chem Inf Model. 2020 Oct 26;60(10):5162-5171. doi: 10.1021/acs.jcim.9b00989. Epub 2020 Aug 31. PMID: 32818373.

15: Feng HT, Li Y, Duan X, Wang X, Qi C, Lam JWY, Ding D, Tang BZ. Substitution Activated Precise Phototheranostics through Supramolecular Assembly of AIEgen and Calixarene. J Am Chem Soc. 2020 Sep 16;142(37):15966-15974. doi: 10.1021/jacs.0c06872. Epub 2020 Sep 3. PMID: 32813513.

16: Abdel-Haleem FM, Gamal E, Rizk MS, El Nashar RM, Anis B, Elnabawy HM, Khalil ASG, Barhoum A. t-Butyl calixarene/Fe2O3@MWCNTs composite- based potentiometric sensor for determination of ivabradine hydrochloride in pharmaceutical formulations. Mater Sci Eng C Mater Biol Appl. 2020 Nov;116:111110. doi: 10.1016/j.msec.2020.111110. Epub 2020 Jun 5. PMID: 32806318.

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18: Mattiuzzi A, Lenne Q, Carvalho Padilha J, Troian-Gautier L, Leroux YR, Jabin I, Lagrost C. Strategies for the Formation of Monolayers From Diazonium Salts: Unconventional Grafting Media, Unconventional Building Blocks. Front Chem. 2020 Jul 14;8:559. doi: 10.3389/fchem.2020.00559. PMID: 32766206; PMCID: PMC7381217.

19: Di Costanzo L, Geremia S. Atomic Details of Carbon-Based Nanomolecules Interacting with Proteins. Molecules. 2020 Aug 4;25(15):3555. doi: 10.3390/molecules25153555. PMID: 32759758; PMCID: PMC7435792.