FANFT

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 535746

CAS#: 24554-26-5

Description: FANFT is a potent nitrofuran derivative tumor initiator. It causes bladder tumors in all animals studied and is mutagenic to many bacteria.


Chemical Structure

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FANFT
CAS# 24554-26-5

Theoretical Analysis

MedKoo Cat#: 535746
Name: FANFT
CAS#: 24554-26-5
Chemical Formula: C8H5N3O4S
Exact Mass: 239.0001
Molecular Weight: 239.205
Elemental Analysis: C, 40.17; H, 2.11; N, 17.57; O, 26.75; S, 13.40

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: FANFT

IUPAC/Chemical Name: Formamide, N-(4-(5-nitro-2-furanyl)-2-thiazolyl)-

InChi Key: ZQBWQLJJMGJREB-UHFFFAOYSA-N

InChi Code: InChI=1S/C8H5N3O4S/c12-4-9-8-10-5(3-16-8)6-1-2-7(15-6)11(13)14/h1-4H,(H,9,10,12)

SMILES Code: O=CNC1=NC(C2=CC=C([N+]([O-])=O)O2)=CS1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 239.205 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Dawley RM, Lakshmi VM, Babu SR, Zenser TV, Davis BB. Liver NADPH-dependent oxidation of the 5-nitrofurans, FANFT and ANFT, by guinea pig and rat. Xenobiotica. 1993 Feb;23(2):193-203. doi: 10.3109/00498259309059374. PMID: 8498082.

2: Sawczuk IS, Walsh W, King W, Olsson CA, Nguyen-Huu C. Enhanced expression of Harvey-ras oncogene in FANFT-induced transitional cell carcinoma. Urol Int. 1987;42(5):321-5. doi: 10.1159/000281983. PMID: 3433577.

3: Anderström C, Johansson SL, von Schultz L. The influence of phenacetin or mechanical perforation on the development of renal pelvic and urinary bladder tumors in FANFT-induced urinary tract carcinogenesis. Acta Pathol Microbiol Immunol Scand A. 1983 Sep;91(5):373-80. doi: 10.1111/j.1699-0463.1983.tb02768.x. PMID: 6613585.

4: Pauli BU, Cohen SM, Weinstein RS. Cellular changes in rat urinary bladder carcinomas induced by FANFT: a quantitative electron microscopic analysis. J Urol. 1983 Mar;129(3):646-52. doi: 10.1016/s0022-5347(17)52271-5. PMID: 6834570.

5: Crabtree WN, Soloway MS, Matheny RB Jr, Murphy WM. Metastatic characteristics of four FANFT-induced murine bladder tumors. Urology. 1983 Nov;22(5):529-31. doi: 10.1016/0090-4295(83)90235-2. PMID: 6649210.

6: Drago JR. The Noble rat bladder cancer model. FANFT-induced tumors. Cancer. 1984 Mar 1;53(5):1093-9. doi: 10.1002/1097-0142(19840301)53:5<1093::aid- cncr2820530513>3.0.co;2-8. PMID: 6692301.

7: Mickey DD, Mickey GH, Murphy WM, Niell HB, Soloway MS. In vitro characterization of four N-[4-(5-nitro-2-furyl)-2-thiazolyl] formamide (FANFT) induced mouse bladder tumors. J Urol. 1982 Jun;127(6):1233-7. doi: 10.1016/s0022-5347(17)54305-0. PMID: 7087044.

8: Debiec-Rychter M, Jones RF, Zukowski K, Wang CY. Oncogene expression of FANFT- or BBN-induced rat urothelial cells. Int J Cancer. 1990 Nov 15;46(5):913-8. doi: 10.1002/ijc.2910460527. PMID: 2228319.

9: Soloway MS, Cohen SM, Dekernion JB, Persky L. Failure of ascorbic acid to inhibit FANFT-induced bladder cancer. J Urol. 1975 Apr;113(4):483-6. doi: 10.1016/s0022-5347(17)59506-3. PMID: 1117519.

10: Cohen SM, Ellwein LB, Okamura T, Masui T, Johansson SL, Smith RA, Wehner JM, Khachab M, Chappel CI, Schoenig GP, et al. Comparative bladder tumor promoting activity of sodium saccharin, sodium ascorbate, related acids, and calcium salts in rats. Cancer Res. 1991 Apr 1;51(7):1766-77. PMID: 2004360.