Hydromethylthionine HBr
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MedKoo CAT#: 330057

CAS#: 951131-15-0 (HBr)

Description: Hydromethylthionine, also known as LMTM and Leucomethylene Blue, is a apotent tau aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia. Hydromethylthionine showed pharmacological activity on brain structure and function as both monotherapy and as an add-on to symptomatic treatment in certain patients with Alzheimer’s disease.


Chemical Structure

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Hydromethylthionine HBr
CAS# 951131-15-0 (HBr)

Theoretical Analysis

MedKoo Cat#: 330057
Name: Hydromethylthionine HBr
CAS#: 951131-15-0 (HBr)
Chemical Formula: C16H21Br2N3S
Exact Mass: 0.00
Molecular Weight: 447.233
Elemental Analysis: C, 42.97; H, 4.73; Br, 35.73; N, 9.40; S, 7.17

Price and Availability

Size Price Availability Quantity
25mg USD 250 2 Weeks
50mg USD 450 2 Weeks
100mg USD 750 2 Weeks
200mg USD 1250 2 Weeks
500mg USD 2650 2 Weeks
1g USD 3650 2 Weeks
2g USD 6250 2 Weeks
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Related CAS #: 613-11-6 (free base)   1236208-20-0 (mesylate)   61-73-4 (chloride)   951131-15-0 (HBr)  

Synonym: Hydromethylthionine HBr; TRX-0237 HBr; TRX-0237 dihydrobromide; TRX0237; TRX 0237; Leucomethylene Blue dihydrobromide; Leukomethylene Blue dihydrobromide; Reduced methylene Blue dihydrobromide;

IUPAC/Chemical Name: N3,N3,N7,N7-Tetramethyl-10H-phenothiazine-3,7-diamine dihydrobromide

InChi Key: JAUPSVVTGFBHTN-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H19N3S.2BrH/c1-18(2)11-5-7-13-15(9-11)20-16-10-12(19(3)4)6-8-14(16)17-13;;/h5-10,17H,1-4H3;2*1H

SMILES Code: CN(C)C1=CC(SC2=CC(N(C)C)=CC=C2N3)=C3C=C1.[H]Br.[H]Br

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 447.23 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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