Calaxin

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 412228

CAS#: 30412-86-3

Description: Calaxin is a biochemical.


Chemical Structure

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Calaxin
CAS# 30412-86-3

Theoretical Analysis

MedKoo Cat#: 412228
Name: Calaxin
CAS#: 30412-86-3
Chemical Formula: C19H20O6
Exact Mass: 344.126
Molecular Weight: 344.36
Elemental Analysis: C, 66.27; H, 5.85; O, 27.88

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Calaxin

IUPAC/Chemical Name: 2-Propenoic acid, 2-methyl-, 2,3,3a,4,5,6,7,11a-octahydro-6,10-dimethyl-3-methylene-2,7-dioxo-6,9-epoxycyclodeca(b)furan-4-yl ester, (3aR-(3aR*,4R*,6R*,10Z,11aR*))-

InChi Key: RYBHZNMPMHOBAR-IRNKKCRZSA-N

InChi Code: InChI=1S/C19H20O6/c1-9(2)17(21)24-14-8-19(5)15(20)7-12(25-19)10(3)6-13-16(14)11(4)18(22)23-13/h6-7,13-14,16H,1,4,8H2,2-3,5H3/b10-6-/t13-,14-,16+,19-/m1/s1

SMILES Code: C=C(C)C(O[C@@H]([C@](C1=C)([H])[C@]2([H])OC1=O)C[C@](O3)(C)C(C=C3/C(C)=C\2)=O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 344.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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Reconstitution Calculator

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1: Sasaki K, Shiba K, Nakamura A, Kawano N, Satouh Y, Yamaguchi H, Morikawa M, Shibata D, Yanase R, Jokura K, Nomura M, Miyado M, Takada S, Ueno H, Nonaka S, Baba T, Ikawa M, Kikkawa M, Miyado K, Inaba K. Publisher Correction: Calaxin is required for cilia-driven determination of vertebrate laterality. Commun Biol. 2019 Jul 4;2(1):254. doi: 10.1038/s42003-019-0512-5. Erratum for: Commun Biol. 2019 Jun 20;2:226. PMID: 32616902.

2: Sasaki K, Shiba K, Nakamura A, Kawano N, Satouh Y, Yamaguchi H, Morikawa M, Shibata D, Yanase R, Jokura K, Nomura M, Miyado M, Takada S, Ueno H, Nonaka S, Baba T, Ikawa M, Kikkawa M, Miyado K, Inaba K. Erratum: Publisher Correction: Calaxin is required for cilia-driven determination of vertebrate laterality. Commun Biol. 2019 Jul 4;2:254. doi: 10.1038/s42003-019-0512-5. Erratum for: Commun Biol. 2019 Jun 20;2:226. PMID: 31286071; PMCID: PMC6609717.

3: Sasaki K, Shiba K, Nakamura A, Kawano N, Satouh Y, Yamaguchi H, Morikawa M, Shibata D, Yanase R, Jokura K, Nomura M, Miyado M, Takada S, Ueno H, Nonaka S, Baba T, Ikawa M, Kikkawa M, Miyado K, Inaba K. Calaxin is required for cilia- driven determination of vertebrate laterality. Commun Biol. 2019 Jun 20;2:226. doi: 10.1038/s42003-019-0462-y. Erratum in: Commun Biol. 2019 Jul 4;2:254. Erratum in: Commun Biol. 2019 Jul 4;2(1):254. PMID: 31240264; PMCID: PMC6586612.

4: Shojima T, Hou F, Takahashi Y, Matsumura Y, Okai M, Nakamura A, Mizuno K, Inaba K, Kojima M, Miyakawa T, Tanokura M. Crystal structure of a Ca2+-dependent regulator of flagellar motility reveals the open- closed structural transition. Sci Rep. 2018 Jan 31;8(1):2014. doi: 10.1038/s41598-018-19898-7. PMID: 29386625; PMCID: PMC5792641.

5: Mizuno K, Shiba K, Yaguchi J, Shibata D, Yaguchi S, Prulière G, Chenevert J, Inaba K. Calaxin establishes basal body orientation and coordinates movement of monocilia in sea urchin embryos. Sci Rep. 2017 Sep 7;7(1):10751. doi: 10.1038/s41598-017-10822-z. PMID: 28883641; PMCID: PMC5589754.

6: Shiba K, Inaba K. Inverse relationship of Ca2+-dependent flagellar response between animal sperm and prasinophyte algae. J Plant Res. 2017 May;130(3):465-473. doi: 10.1007/s10265-017-0931-7. Epub 2017 Apr 19. PMID: 28424932.

7: Wang T, Lu M, Du Q, Yao X, Zhang P, Chen X, Xie W, Li Z, Ma Y, Zhu Y. An integrated anti-arrhythmic target network of compound Chinese medicine Wenxin Keli revealed by combined machine learning and molecular pathway analysis [corrected]. Mol Biosyst. 2017 May 2;13(5):1018-1030. doi: 10.1039/c7mb00003k. Erratum in: Mol Biosyst. 2017 Sep 26;13(10):2181. PMID: 28418441.

8: Wang X, Liu B, Liu F, Huan P. A Calaxin Gene in the Pacific Oyster Crassostrea gigasand Its Potential Roles in Cilia. Zoolog Sci. 2015 Oct;32(5):419-26. doi: 10.2108/zs150009. PMID: 26428718.

9: Inaba K. Calcium sensors of ciliary outer arm dynein: functions and phylogenetic considerations for eukaryotic evolution. Cilia. 2015 Apr 30;4:6. doi: 10.1186/s13630-015-0015-z. PMID: 25932323; PMCID: PMC4415241.

10: Mizuno K, Shiba K, Okai M, Takahashi Y, Shitaka Y, Oiwa K, Tanokura M, Inaba K. Calaxin drives sperm chemotaxis by Ca²⁺-mediated direct modulation of a dynein motor. Proc Natl Acad Sci U S A. 2012 Dec 11;109(50):20497-502. doi: 10.1073/pnas.1217018109. Epub 2012 Nov 20. PMID: 23169663; PMCID: PMC3528578.

11: Mizuno K, Padma P, Konno A, Satouh Y, Ogawa K, Inaba K. A novel neuronal calcium sensor family protein, calaxin, is a potential Ca(2+)-dependent regulator for the outer arm dynein of metazoan cilia and flagella. Biol Cell. 2009 Feb;101(2):91-103. doi: 10.1042/BC20080032. PMID: 18620543.